骨组织工程支架材料合成技术的进展

组织工程骨是由人工支架材料体外复合扩增的成骨细胞或其前体细胞及生物活性分子构成,高孔隙支架材料在细胞黏附、增殖和新骨组织形成过程中起到最重要的作用。过去的十年,产生和发展了许多合成生物可降解支架材料的技术,骨组织工程研究取得了可喜的成绩。本文主要是回顾这些技术在支架材料的设计、制做工艺,以及各种技术不同参数对支架材料(孔隙率、孔径大小、孔隙连通率等)的影响,阐述不同技术的发展过程的优缺点。

Current development of scaffold design and fabrication in bone tissue engineering

With the development of tissue engineering,the bone tissue engineering is developing rapidly. Engineering hone typically uses an artificial extracellular matrix (scaffold),osteoblasts or progenitors,and os- teoinductive factors which promote cell attachment,differentiation,and mineralized bone formation.Highly porous scaffolds play a critical role in cell seeding,proliferation,and new 3D-tissue formation.A variety of biodegradable polymer materials and scaffolding fabrication techniques for engineering bone have been developed over the past decade.This article reviews the scaffold design and fabrication methods tor engineering bone to analyze their ad- vantages and limitations.Various architectural parameters of scaffolds important for bone tissue engineering (e.g. porosity,pore size,interconnectivity) are discussed.