| 高乌甲素贴片释放度测定的研究 |
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| 引用本文： | 黄涤非,徐金星,于曼那.高乌甲素贴片释放度测定的研究[J].药学实践杂志,1997,15(1):23-25. |
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| 作者姓名： | 黄涤非 徐金星 于曼那 |
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| 作者单位： | 第三军医大学新桥医院麻醉科!重庆，630037，第三军医大学新桥医院麻醉科!重庆，630037，第三军医大学新桥医院麻醉科!重庆，630037 |
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| 摘 要： | 本文通过体内及体外实验观察了纳络酮对正常、缺血和再灌注心肌腺苷酸环化酶（AC）活性的影响。其结果表明：静脉注射纳络因（1mg．kg-1）可以明显降低缺血、再灌注心肌AC活性（P＜0．01，P＜0．05）；但纳络酮在体外对正常、缺血和再灌注心肌组织匀浆AC活性无明显抑制作用（P＞0．05）。提示：纳络酮本身对AC活性无直接抑制作用，它降低缺血、再灌注心肌AC活性可能与酶前调节有关。
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| 关 键 词： | 心肌 腺苷酸环化酶 纳络酮 |
Effect of naloxone on adenylcyclase activity of canine myocardium |
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| Yang Tiande,Liu Qiaoyi,Wang Zhouqi.Effect of naloxone on adenylcyclase activity of canine myocardium[J].The Journal of Pharmaceutical Practice,1997,15(1):23-25. |
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| Authors: | Yang Tiande Liu Qiaoyi Wang Zhouqi |
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| Abstract: | To elucidate the effect of naloxone on adenylcyclase(AC) of canine myocardium,the adenylcyclase activities of non-ischemic, ischemic and reper fused myocardium were assayed respectively in vivo and in vitro. It was found that intravascular administration of naloxone(1mg.kg-1) significantly decreased AC activities of ischemic and reper fused myocardium(p<0.01, p<0.05);but naloxone had no effect on AC activities in non-ischemic, ischemic and reperfused myocardium homogenate(p>0.05). It suggested that naloxone have no direct inhibiting effect on activity. |
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| Keywords: | myocardium naloxone adenylcyclase |
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