| 大鼠海马神经元核受体-糖皮质激素受体在穹窿切断同时摘除肾上腺后表达的变化 |
| |
| 引用本文： | 张彦慧,石玉秀,符皎荣,郑小桃,钟南田,洪灯.大鼠海马神经元核受体-糖皮质激素受体在穹窿切断同时摘除肾上腺后表达的变化[J].神经解剖学杂志,2010,26(2). |
| |
| 作者姓名： | 张彦慧 石玉秀 符皎荣 郑小桃 钟南田 洪灯 |
| |
| 作者单位： | 1. 海南医学院组织学与胚胎学教研室,海口,571101
2. 中国医科大学组织学与胚胎学教研室,沈阳,110001 |
| |
| 摘 要： | 目的:通过建立穹窿切断的动物模型来检测糖皮质激素的浓度和穹窿切断同时摘除肾上腺的动物模型检测海马神经元核受体-糖皮质激素受体(GR)的表达变化,以探讨GR参与下丘脑-垂体-肾上腺(HPA)轴调节的机制。方法:建立大鼠穹窿切断模型,采用ELISA方法检测穹窿切断0,4,7,10d血中糖皮质激素的浓度、建立大鼠穹窿切断同时摘除肾上腺7d的模型,采用免疫组织化学、免疫印迹方法检测海马神经元核受体GR表达变化的观察及定量检测。结果:穹窿切断7d后血中糖皮质激素的浓度升高,穹窿切断同时摘除肾上腺7d后,海马神经元GR表达升高。结论:海马核受体GR的表达变化可能与糖皮质激素的浓度呈负相关。
|
| 关 键 词： | 穹窿切断术 穹窿切断同时摘除肾上腺 核受体-糖皮质激素受体 海马 神经元 |
Expression of nuclear receptor-glucocorticoid receptors in the hippocampal neurons after fornix transection and adrenalectomy |
| |
| Zhang Yanhui,Shi Yuxiu,Fu Jiaorong,Zheng Xiaotao,Zhong Nantian,Hong Deng.Expression of nuclear receptor-glucocorticoid receptors in the hippocampal neurons after fornix transection and adrenalectomy[J].Chinese Journal of Neuroanatomy,2010,26(2). |
| |
| Authors: | Zhang Yanhui Shi Yuxiu Fu Jiaorong Zheng Xiaotao Zhong Nantian Hong Deng |
| |
| Institution: | Zhang Yanhui1,Shi Yuxiu2,Fu Jiaorong1,Zheng Xiaotao1,Zhong Nantian1,Hong Deng1(1. Department of Histology , Embryology,Hainan Medical College,Haikou 571101,2. Department of Histology , Embryology,China Medical University,Shenyang 110001,China) |
| |
| Abstract: | Objective:To investigate the concentration of glucocorticoid after fornix transection,expression of glucocorticoid receptor (GR) which is one of neuclear receptors in the hippocampal neurons after fornix transection and adrenalectomy,and to explore the mechanisms of glucocorticoid receptor participation in regulating (HPA) hypothalamic-pituitary-adrenal axis. Methods:The fornix was transected to establish a animal model,ELISA was used for detection of glucocorticoid concentrations on day 0,4,7 and 10 after ... |
| |
| Keywords: | fornix transection fornix transection and adrenalectomy nuclear receptor-mineralcorticoid receptor hippocampus neuron |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
