15例子宫内膜浆液性乳头状癌临床资料分析

[目的]探讨子宫内膜浆液性乳头状癌（uterine papillary serous carcinoma,UPSC）的临床病理特征以及合理的治疗方法。[方法]对1995年1月-2007年12月收治的15例UPSC患者进行回顾性研究,对其发病趋势、危险因素、临床表现、病理特征、诊断方法和治疗方案进行分析。[结果]平均发病年龄63.8岁,80%患者雌孕激素受体阴性,53.3%患者术后手术病理分期高于术前临床分期,P53在60%患者中有表达,中晚期患者血清CA-125水平均有升高。所有患者均接受手术治疗,多数术后辅助化疗、放疗,生存率仍较低。[结论]UPSC不同于子宫内膜样腺癌,具有其特殊性,恶性程度较高,预后差。合理的个体化综合治疗可提高生存率。

Clinical analysis of 15 cases of uterine papillary serous carcinoma

[Objective] To investigate the clinical and pathologic characteristics,and search the rational therapy for uterine papillary serous carcinoma(UPSC).[Methods] A retrospective study was conducted on incidence,risk factors,clinical characters,pathological feature,diagnosis and treatment of 15 patients with UPSC,who was admitted from Jan.1995 to Dec.2007.[Results] Median age at diagnosis was 63.8 years.Among all the patients with UPSC,80% presented negative estrogen and/or progestin receptor,53.3% diagnosed as ...