Discriminative response control by d-amphetamine and related compounds in the rat |
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| Authors: | Catherine N. Jones Harlan F. Hill Robert T. Harris |
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| Affiliation: | (1) Texas Research Institute for Mental Sciences, 1200 Moursund, Houston, Texas;(2) 229 Biological Sciences Research Center, Child Development Institute UNC Medical School, 27514 Chapel Hill, North Carolina, USA;(3) Present address: Department of Neuropharmacology, Smith, Kline and French Laboratories, 1500 Spring Garden Street, Philadelphia, Pennsylvania;(4) Present address: Department of Physiology, Baylor College of Medicine, 1200 Moursund, Houston, Texas |
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| Abstract: | Rats were trained to discriminate between two levers utilizing drug-induced physiological states as discriminative stimuli. Drug injections were associated with reinforcement of response on one lever and saline was associated with reinforcement on the other lever. At equimolar doses, d- and l-amphetamine but not para-hydroxyamphetamine, functioned effectively as cues. Following training, stimulus generalization between these drugs was evaluated. Transfer of response control was observed between the d- and l-isomers, and between para-hydroxyamphetamine and saline in rats trained to utilize d- or l-amphetamine versus saline as cues. These findings suggest the importance of central pharmacological activity in this type of response control.This research was supported by National Institute of Mental Health Grant MH-19651. |
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| Keywords: | d-Amphetamine l-Amphetamine Para-Hydroxyamphetamine Appetitive Discrimination Drug Cues |
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