慢性高原病肝功能及血清酶的改变

目的探讨慢性高原病(CMS)患者肝功能及血清酶的变化。方法选择移居海拔4300m3个月以上的汉族男性青年323名,其中CMS患者87名,为CMS组,其余236名为非CMS组。清晨抽取空腹静脉血检测血清总胆红素(STB)、直接胆红素(SDB)、总蛋白(TP)、清蛋白(BLA)、丙氨酸氨基转换酶(ALT)、门冬氨酸氨基转换酶(AST)、γ-谷氨酰转移酶(γ-GT)、碱性磷酸酶(ALP)。以血红蛋白(18g<血红蛋白<21g,记0分,血红蛋白≥21g,记3分)及动脉血氧饱和度(动脉血氧饱和度≤85%,记3分)记分。分别以1,2,3分表示轻、中、重度。无CMS总记分为0~5分,轻度为6~10分,中度为11~14分,重度为15分或更高。结果CMS组较非CMS组STB,AST,ALT,γ-GT增高,有显著性差异(P<0.05);TP,BLA降低,有非常显著性差异(P<0.01),SDB,ALP无统计学差异(P>0.05)。结论CMS引起肝功能指标及血清酶活性异常,提示CMS伴有多种器官或组织受损。

Liver Function and Serum Enzyme Changes of Chronic Mountain Sickness

Objective To explore the liver function and the serum enzyme changes of chronic mountain sickness (CMS) sufferers. Methods A total of 323 youth who stayed at a high altitude of 4,300 meters for more than three months were inspected for serum total bilirubin (STB), serum direct bilirubin (SDB), total protein (TP), albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase (γ-GT) and alkalinephosphatase (ALP). Count points on hemoglobin (Hb) and oxygen saturation (SaO_2) were recorded (18g0.05). Conclusion CMS leads to the changes in liver function and serum enzyme activity, which indicates that multiple organs and tissue are damaged.