冻融胚胎移植周期中不同辅助生殖技术助孕方式和移植不同发育阶段胚胎对出生性别比的影响

目的:探讨冻融胚胎移植（frozen-thawed embryo transfer， FET）周期中不同辅助生殖技术（assisted reproductive technology， ART）助孕方式和移植不同发育阶段胚胎对新生儿性别的影响。方法:回顾性队列研究分析2010年4月至2018年10月期间于广州市妇女儿童...

Sex ratio at birth of different assisted reproductive technologies and embryo transfer at different developmental stages in frozen-thawed embryo transfer cycles

Objective To investigate the effect of different assisted reproductive technologies(ART)and transplanted embryos at different developmental stages on live birth sex ratio in frozen-thawed embryo transfer(FET)cycles.Methods From April 2010 to October 2018,the clinical data of patients and neonatal underwent in vitro fertilization-frozen-thawed embryo transfer(IVF-FET),intracytoplasmic sperm injection-frozen-thawed embryo transfer(ICSI-FET)and preimplantation genetic testing-frozen-thawed embryo transfer(PGT-FET)cycles that led to birth in the Center of Reproductive Medicine,Guangzhou Women and Children's Medical Center were retrospectively analyzed.The relationship of the sex ratio of the live births to different ART and transplanted embryos at different developmental stages was studied.Results 1)IVF-FET cycles included 898 couples(920 FET cycles)and 1166 babies,with a general sex ratio of 106.7.The live birth sex ratio increased gradually at pre-morula stage,morula stage and blastocyst stage embryo transfer(99.0,135.4,142.6),but no statistical difference was observed between the groups(P>0.05).2)ICSI-FET cycles included 415 couples(433 FET cycles)and 555 babies,with a general live birth sex ratio of 111.0.After the transfer of embyos at different stages the proportion of male babies displayed no significant difference(P>0.05).3)PGT-FET cycles included 33 couples(33 FET cycles)and 33 babies,with a general live birth sex ratio of 153.8.Transplantation of blastocysts in IVF,ICSI or PGT had no significant effect on the proportion of male babies(P>0.05).Conclusion In FET cycles,compared with embryo transfer at early stage,late stage embryo transfer may be associated with a higher live birth sex ratio.The transfer of ICSI-FET embryos at different developmental stages and the transfer of blastocysts by IVF,ICSI or PGT technique did not affect the sex ratio of live birth.