胸腺角蛋白的免疫组化观察

观察122例尸检胸腺组织的角蛋白免疫组化反应(PAP法),呈阳性反应的网状上皮细胞,其数量和分布在不同的病理情况下表现不同,且与年龄有关,在20岁以下的胸腺呈重度病理性萎缩的35例中,有29例(82.9%)其网状上皮细胞的数量增多,在麻疹后肺炎、间质性肺炎和恶性肿瘤的患者特别明显,其严重变化者,与文献中报道艾滋病(AIDS)的胸腺变化相近似。在20岁以上的7例中,有6例胸腺仅有微量网状上皮细胞,且在不同疾病和死因之间,无明显差异。

Anti-Keratin Immunohistochemical Study on Thymus

This paper reports the anti-keratin immuno histochemical reaction(PAP)on the thymus of 122 necropsies.The positive reactive cellsof anti-keratin antibodies are reticulo-epithelial cells and undegener-ative Hassall's corpuscles.The amount and distribution of these pos-itive cells vary in different pathological conditions and ages ofpatients.In the group under 20 years of age,there are 35 casesof severe pathological atrophy of thymus,in which 29 cases(82.9%)had more dense positive cells in the lobuls,especially inthe cases of post-measles pneumonia,interstitial pneumonia and ma-lignant tumors,and some like the alterations of AIDS'S thymus inthe literatures But all of the group of above 20 years of age revealedphysiological involution,while 6 of the 7 cases only few positivecells could be found and did not vary with different diseases andcauses of death.