| CD44v6、nm23-H1在卵巢癌中的表达及其临床意义的研究 |
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| 引用本文： | 曲群,刘明,杨整哉,宗璐. CD44v6、nm23-H1在卵巢癌中的表达及其临床意义的研究[J]. 山西医科大学学报, 2003, 34(3): 271-273 |
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| 作者姓名： | 曲群 刘明 杨整哉 宗璐 |
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| 作者单位： | 西安交通大学第二医院妇产科,西安,710004 |
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| 摘 要： | 目的 探讨CD44v6和nm23-H1在卵巢癌中的表达与临床病理指标的关系。方法 应用免疫组化SABC方法，对50例卵巢癌标本进行CD44v6和nm23-H1蛋白测定。结果 CD44v6高表达和nm23-H1低表达与卵巢癌淋巴结转移有关(P＜0．05)；CD44V6阳性表达伴nm23-H1阴性表达者发生淋巴转移的可能性大。结论 CD44v6和nm23-H1与卵巢癌淋巴结转移密切相关，两者在淋巴结转移中起协同作用。联合检测对判断卵巢癌淋巴结转移，估计预后是一项有用指标。
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| 关 键 词： | 卵巢癌 CD44v6 nm23－H1 免疫组织化学 淋巴结转移癌 |
| 文章编号： | 1007-6611(2003)03-0271-03 |
Expression and clinical significance of CD44v6 and nm23-H1 in ovarian carcinoma |
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| QU Qun,LIU Ming,YANG Zheng zai,et al. Expression and clinical significance of CD44v6 and nm23-H1 in ovarian carcinoma[J]. Journal of Shanxi Medical University, 2003, 34(3): 271-273 |
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| Authors: | QU Qun LIU Ming YANG Zheng zai et al |
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| Abstract: | Objective To study the expression of CD44v6 and nm23 H1 and their clinical significance in ovarian carcinoma. Methods CD44v6 and nm23 H1 expressions were determined in 50 cases of ovarian carcinoma by immunohisto chemical method SABC. Results Over expression of CD44v6 and low expression of nm23 H1 were closely related with lymph node metastasis ( P <0 05), and patients with positive CD44v6 expression and negative nm23 H1 expression were more likely to have lymph node metastasis. Conclusion Expression of CD44v6 and nm23 H1 are closely related with lymph node metastasis, which may serve as an important indicator of metastasis and an index of the prognosi in ovarian carcinoma. |
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