Inverter mechanism of the influence exerted by insulin on the plasma membranes of cardiac myocytes in rats of different age |
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Authors: | V. V. Frol'kis O. K. Kul'chitskii E. N. Gorban' |
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Affiliation: | (1) Laboratory of Physiology and Laboratory of Metabolic Regulation, Institute of Gerontology, Ukrainian Academy of Medical Sciences, Kiev |
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Abstract: | In the plasma membranes of cardiac myocytes from old rats, Na, K-ATPase activity and phosphatidylinositol levels were lower and cardiolipin levels higher than in those from younger (adult) animals. Insulin injected into adult rats elevated Na, K-ATPase activity and phosphatidylethanolarnine levels and caused a sharp fall in phosphatidylinositol levels. In old rats, insulin had no effect on Na, K-ATPase activity, but lowered phosphatidylethanolamine levels. In experiments with cellular hybrids (cytosol+plasma membranes), cytosol from adult rats activated Na, K-ATPase in both adult and old rats, whereas cytosol from old rats failed to activate the enzyme both in old and in adult rats. Actinomycin D prevented the stimulatory effect of insulin on Na,K-ATPase activity. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N o 8, pp. 122–125, August, 1995 |
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Keywords: | insulin myocardium membranes aging |
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