农药唑呀威毒理及中毒治疗的实验研究

唑呀威（Ｔｒｉａｚｕｒｏｎ）系新型的高效杀蚜虫剂。目前，对其抑制胆碱酯酶活性的毒理尚报道不一。作者在进行毒性测试和发现１６名包装工夏季作业时８名出现明显症状的基础上，开展动物实验研究。结果发现，唑呀威有较有机磷农药更为快速的胆碱酯酶抑制作用，大鼠经口染毒１１２．５ｍｇ／ｋｇ仅３０ｍｉｎ内即见全血胆碱酯酶活性显著下降，Ｐ＜０．０１；且存在明显剂量－反应关系。高剂量（２００ｍｇ／ｋｇ）还可引起心血管系统的损害。注射阿托品有显著解救效果，染毒同时给药的解救效果明显优于染毒后５分钟给药，提示愈早给药解救效果愈好。作者由此提出了临床中毒急救措施的建议

TOXICITY AND EXPERIMERNTAL THERAPY STUDIES OF TRIAZURON

riazuron, ethyl(3 tert butyl 1 dimethyl carbamoyl 1H 1,2,4 triazol 5 ylsulfur)acetate, is a new highly selective fast acting systemic aphicide. This paper describes the mechanism of its toxicity and experimental therapy studies of Triazuron. Acute toxicological data for pure material are: rat oral LD 50 200mg/kg, acute dermal LD 50 >5000mg/kg. No skin irritation and teratogensis were found. Among the 16 workers there are 8 workers appeared illness during packing Triazuron in summer season. Animal studies shown Triazuron is a fast acting cholinesterase inhibitor. High dose (200mg/kg) could deteriorating cardiac function. Prophylaxis and treatment were suggested by authors.