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| 微透析技术在抗菌药物药动学和药效学中的应用 | |
| 引用本文： | 刘德鼎,黄怡,肖和平,刘瑞.微透析技术在抗菌药物药动学和药效学中的应用[J].药学服务与研究,2010,10(3):212-216. |
| 作者姓名： | 刘德鼎 黄怡 肖和平 刘瑞 |
| 作者单位： | 1. 第二军医大学长海医院普外科,上海,200433 2. 第二军医大学长海医院呼吸内科,上海,200433 3. 上海市肺科医院结核科,上海,200433 |
| 摘 要： | 微透析技术是一项新兴的体内药物分析技术。通过微透析技术与药动学和药效学模型结合,实现对组织或细胞外游离态药物浓度及其相应药理效应的同时研究,不仅有利于进一步明确药物的剂量-效应关系,制定临床最佳给药方案,而且也为个体化给药提供了科学依据。本文综合近年文献,对微透析技术的基本原理以及在抗菌药物药动学和药效学研究中的应用作一综述。 |
| 关 键 词： | 微透析 抗感染药 药代动力学 药效学 综述 |
Application of microdialysis technique in pharmacokinetic and pharmacodynamic studies of antimicrobials |
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| LIU Deding,HUANG Yi,XIAO Heping,LIU Rui.Application of microdialysis technique in pharmacokinetic and pharmacodynamic studies of antimicrobials[J].Pharmaceutical Care and Research,2010,10(3):212-216. | |
| Authors: | LIU Deding HUANG Yi XIAO Heping LIU Rui |
| Institution: | 1.Department of General Surgery,Changhai Hospital,Second Military Medical University,Shanghai 200433,China;2.Department of Respiratory Disease,Changhai Hospital,Second Military Medical University,Shanghai 200433,China;3.Department of Tuberculosis Disease,Shanghai Pulmonary Hospital,Shanghai 200433,China ) |
| Abstract: | Microdialysis is an appealing technique which was developed for in vivo analysis of drugs.When microdialysis was integrates with pharmacokinetic and pharmacodynamic models,it allows to study free drug concentration in tissues and outside of cells,and the corresponding pharmacologic effects,which not only is beneficial to clarification of dosage-effect relationship of drugs and working out the optimal dose regimen,but also provides scientific basis for formulating individualized medication.In this paper,basic principle and application of microdialysis in pharmacokinetic and pharmacodynamic studies of antimicrobials are reviewed. |
| Keywords: | microdialysis anti-infective agents phamacokinetics phamacodynamics review |
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