Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells |
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Authors: | Pacholczyk Rafal Kern Joanna Singh Nagendra Iwashima Makio Kraj Piotr Ignatowicz Leszek |
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Institution: | Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA 30912, USA. rpacholczyk@mcg.edu |
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Abstract: | The majority of regulatory Foxp3+CD4+ T cells naturally arises in the thymus. It has been proposed that T cell receptors (TCRs) on these cells recognize self-MHC class II-peptide complexes with high or higher affinity and that their specificities mirror specificities of autoreactive T cells. Here, we analyzed hundreds of TCRs derived from regulatory or nonregulatory T cells and found little evidence that the former population preferably recognizes self-antigens as agonists. Instead, these cells recognized foreign MHC-peptide complexes as often as nonregulatory T cells. Our results show that high-affinity, autoreactive TCRs are rare on all CD4+ T cells and suggest that selecting self-peptide is different from the peptide that activates the same regulatory T cells in the periphery. |
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