| The study of 3-dimensional structures of IgG with atomic force microscopy |
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| 引用本文： | 郁毅刚,徐如祥,姜晓丹,柯以铨. The study of 3-dimensional structures of IgG with atomic force microscopy[J]. 中华创伤杂志(英文版), 2005, 8(5): 277-282 |
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| 作者姓名： | 郁毅刚 徐如祥 姜晓丹 柯以铨 |
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| 作者单位： | Department of Neurosurgery，Zhujiang Hospital，South Medical University，Guangzhou510282，China，Department of Neurosurgery，Zhujiang Hospital，South Medical University，Guangzhou510282，China，Department of Neurosurgery，Zhujiang Hospital，South Medical University，Guangzhou510282，China，Department of Neurosurgery，Zhujiang Hospital，South Medical University，Guangzhou510282，China |
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| 基金项目： | ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina(30170961)andTenth-fiveyearsProjectMedicalScienceFoundationofPLA(01Z054). |
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| 摘 要： | Tsihmteimp eouxrlctaaittnianttog rr oyclae nti eoiunnr-o cbtorrnaanidnsumc itinitnjtuegrr y igo lnaunt cadhma fanutnneec lptsiloa nwyssh iabchnyhave distinct biophysical and pharmacologicalproperties and differ in their binding sites for selectiveagonists and antagonists.1,2NMDA(anti-N-methyl-D-aspartate)receptor widely distributes in the centralnervous system.It is essential not only for its normaldevelopment and plasticity but also for such specializedfunctions as memory or learning.3Espec…
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| 关 键 词： | 三维空间 IgG 免疫球蛋白G 原子能量 显微镜 生物大分子 膜蛋白 |
The study of 3-dimensional structures of IgG with atomic force microscopy |
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| YU Yi-gang,XU Ru-xiang,JIANG Xiao-dan,KE Yi-quan. The study of 3-dimensional structures of IgG with atomic force microscopy[J]. Chinese journal of traumatology, 2005, 8(5): 277-282 |
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| Authors: | YU Yi-gang XU Ru-xiang JIANG Xiao-dan KE Yi-quan |
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| Affiliation: | Department of Neurosurgery, Zhujiang Hospital, South Medical University, Guangzhou 510282, China |
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| Abstract: | OBJECTIVE: To detect 3-dimensional images of anti-N-methyl-D-aspartate receptor Nr1 (NMDAr1) polycolonal IgG affixed on mica in physiological environment. METHODS: The images and data were obtained from a contact mode and commercial Si3N4 probed tip by using atomic force microscope (AFM). RESULTS: The anti-NMDAr1 polycolonal IgG has a characteristic structure described as an ellipse spherical shape of 136.4 A x 62.8 A x 26.1 A. On the section of the ellipse edge there were two peaks about 13 nm in width. CONCLUSIONS: Using AFM to investigate biomacromolecule can make us deeply understand the structure of IgG, which will instruct us to detect the membrane receptor protein as a labelling agent. |
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| Keywords: | Neurons Receptors IgG Microscopy atomic force NMDAr1 |
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