Decrease of hepatic mitochondrial glutathione and mitochondrial injury induced by 1,2-dibromoethane in the rat in vivo: effect of diethylmaleate pretreatment |
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| Authors: | B Botti A Bini A Calligaro E Meletti A Tomasi V Vannini |
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| Affiliation: | 1. Istituto di Patologia Generale, Universitá di Modena, Italy;2. Istituto di Istologia e Embriologia Generale, Universitá di Pavia, Italy;1. Laboratory of Retinal Neurochemistry and Experimental Ophthalmology, Department of Human Biochemistry, School of Medicine/CEFyBO, University of Buenos Aires/CONICET, Buenos Aires, Argentina;2. School of Engineering and Agrarian Sciences, Pontifical Catholic University of Argentina, BIOMED/UCA/CONICET, Buenos Aires, Argentina;3. Interdisciplinary Laboratory of Cellular Dynamics and Nanotools, Department of Biological Chemistry, Faculty of Exact and Natural Sciences/IQUIBICEN, University of Buenos Aires/CONICET, Buenos Aires, Argentina;4. Department of Analytical Chemistry and Physicochemistry, School of Pharmacy and Biochemistry/IBIMOL, University of Buenos Aires/CONICET, Buenos Aires, Argentina;5. Department of Cellular Biology, Histology, Embryology and Genetics, School of Medicine/INBIOMED, UBA/CONICET, Buenos Aires, Argentina;6. Laboratory of Retinal Neurochemistry and Experimental Ophthalmology, Department of Biological Chemistry, Faculty of Exact and Natural Sciences/IQUIBICEN, University of Buenos Aires, Buenos Aires, Argentina;7. Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina;1. State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen 361102, China;2. State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, China;1. Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210008, China;2. Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China;3. Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210008, China |
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| Abstract: | Diethylmaleate (DEM) potentiated the 1,2-dibromoethane (DBE)-induced hepatic morphological lesion in fasted male Wistar rats, as revealed by light and electron microscopy examination. The subcellular structures involved in such lesions were the mitochondria. The potentiating effect of DEM appeared to be due to enhancement of the depletion of hepatic mitochondrial glutathione (GSH) caused by DBE. DEM, however, failed to potentiate the DBE-induced release in the plasma of hepatic enzymes. The relationship between loss of mitochondrial GSH, mitochondrial injury, and the importance of the mitochondrial lesion in DBE-induced hepatotoxicity is discussed. |
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