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| 新型棉酚衍生物ApoG2对人前列腺癌PC-3移植瘤生长的抑制 | |
| 引用本文： | 张献清,黄晓峰,穆士杰,易静,安群星,夏爱军,陈蕤,吴道澄. 新型棉酚衍生物ApoG2对人前列腺癌PC-3移植瘤生长的抑制[J]. 现代肿瘤医学, 2010, 18(2) |
| 作者姓名： | 张献清 黄晓峰 穆士杰 易静 安群星 夏爱军 陈蕤 吴道澄 |
| 作者单位： | 1. 西安交通大学生物医学信息工程教育部重点实验室,陕西,西安,710038;第四军医大学西京医院输血科,陕西,西安,710032 2. 第四军医大学中心实验室,陕西,西安,710032 3. 第四军医大学西京医院输血科,陕西,西安,710032 4. 西安交通大学生物医学信息工程教育部重点实验室,陕西,西安,710038 |
| 摘 要： | 目的:探讨棉酚衍生物ApoG2对前列腺癌的抑制作用,并了解其作用机理.方法:建立人前列腺癌细胞的裸鼠皮下移植瘤模型,在ApoG2作用下观察其对皮下移植瘤生长的抑制作用,通过免疫组化方法检测肿瘤组织中bcl-2、PCNA及caspase-3、-8的表达.结果: ApoG2可明显抑制前列腺癌皮下移植瘤生长速度,肿瘤体积明显减小,ApoG2能增加肿瘤组织中caspase-3、8的表达,减少PCNA表达.结论: ApoG2对人前列腺癌有显著的生长抑制作用. |
| 关 键 词： | 棉酚 前列腺癌 PC-3人前列腺癌细胞系 移植瘤 |
Inhibitory effects of a new gossypol derivative apogossypolone (ApoG2) on subcutaneous implants of human PC-3 prostatic carcinoma cells |
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| ZHANG Xian-qing,HUANG Xiao-feng,MU Shi-jie,YI Jing,AN Qun-xing,XIA Ai-jun,CHEN Rui,WU Dao-cheng. Inhibitory effects of a new gossypol derivative apogossypolone (ApoG2) on subcutaneous implants of human PC-3 prostatic carcinoma cells[J]. Journal of Modern Oncology, 2010, 18(2) | |
| Authors: | ZHANG Xian-qing HUANG Xiao-feng MU Shi-jie YI Jing AN Qun-xing XIA Ai-jun CHEN Rui WU Dao-cheng |
| Affiliation: | ZHANG Xian-qing1,2,HUANG Xiao-feng3,MU Shi-jie2,YI Jing2,AN Qun-xing2,XIA Ai-jun2,CHEN Rui2,WU Dao-cheng11The Key Laboratory of Biomedical Information Engineering of Ministry of Education,Xi'an Jiaotong University,Xi'an 710038,China,2Blood bank,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,3Central laboratory,China. |
| Abstract: | Objective:To investigate the inhibitory effect of apogossypolone(ApoG2) on prostatic carcinoma,and explore its mechanism.Methods: To establish human prostatic carcinoma PC-3 cell line subcutaneous xenograft models and observe the inhibitory effect of ApoG2 on the tumor model.Immunohistochemistry was employed to observe the expression of bcl-2,PCNA,caspase-3 and-8 in tumor tissues.Results: ApoG2 can obviously inhibit the growth of subcutaneous prostatic carcinoma implant.The tumor volume decreased obviously.... |
| Keywords: | Apogossypolone |
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