2型糖尿病患者CD62p、CD63与糖尿病周围神经病变的关系

目的探讨CD62p、CD63与糖尿病周围神经病变（DPN）的关系。方法用流式细胞术测定59例2型糖尿病患者CD62p、CD63,使用Nicolet Viking IVD肌电图诱发电位仪测定周围神经传导速度（NCV）,肌电图正常者为非DPN（A组,25例）,神经电生理异常者为DPN（B组,34例）。健康对照组26例。结果CD62p、CD63的水平在糖尿病与对照组比较有显著差异（P〈0.001,P〈0.01）,B组与A组有显著差异（P〈0.05,P〈0.05）,直线相关分析显示CD62p与CD63（r=0.564,P〈0.001）、FPG（r=O.402,P〈0.01）呈正相关,与左腓MNCV（r=-0.320,P〈0.05）、右腓MNCV（r=-0.299,P〈0.05）、左尺MNCV（r=-0.407,P〈0.01）、右尺SNCV（r=-0.382,P〈0.05）呈负相关,与年龄、病程、GHB、TG、TC、BMI等无相关,CD63与FPG（r=O.623,P〈0.001）呈正相关,与左腓MNCV（r=-0.377,P〈0.01）、右腓MNCV（r=-0.285,P〈0.05）、右尺SNCV（r=-0.378,P〈0.05）呈负相关,与其余因素无相关。结论CD62p、CD63表达率可能是糖尿病周围神经病变发生与发展的一个预测指标。

Relationship between CD62p、CD63 and diabetic peripheral neuropathy in type Ⅱ diabetes patients

Objective To explore the relationship between CD62p、CD63 and diabetic peripheral neuropathy（DPN）in type Ⅱ diabetes patients. Methods FCM was used to test CD62p、CD63 in 59 cases of type Ⅱ diabetes patients, Nicolet Viking IVD electromyologram potential evoker was used to measure the peripheral nerve conduction velocity（ PNCV） , cases normal in electromyologram was none-DPN（ group A , 25 cases ）,cases abnormal in neural electrophysiology was DPN（group B,34 cases）. 26 cases as control group . Results There was significant difference in CD62p、CD63 levels between the diabetes group and the control group （P〈0.001,P〈0.01）, there is significant difference between that of group B and group A , （P〈0.05,P〈0.05）,analysis of linear correlation showed CD62p had positive correlation with CD63（r=0.564,P〈0.001） and FPG（r=0.402,P〈0.01）,while negative correlation with left peroneal nerve,common ＇s MNCV（r=-0.320,P〈0.05）、right peroneal nerve,common ＇s MNCV（r=-0.299,P〈0.05）、left cubital nerve＇s MNCV（r=-0.407,P〈0.01）、right cubital nerve＇s SNCV（r=-0.382,P〈0.05）,CD62p has no relationship with ago course、GHB、TG、TC、BMI, CD63 has a positive correlation with FPG（r=O.623,P〈0.001）while a negative correlation with left peroneal nerve,common＇s MNCV（r=-0.377,P〈0.01）、right peroneal nerve,common＇s MNCV（r=-0.285,P〈0.05）、right cubital nerve＇s SNCV（r=-0.378,P〈0.05）, there was no correlations with other factors .