沙美特罗替卡松粉吸入剂对初入高海拔地区青年一氧化氮及其合酶的影响

目的：探讨沙美特罗替卡松粉吸入剂对初入高海拔地区青年一氧化氮（NO）和一氧化氮合酶（NOS）的影响,为预防和治疗急性高原病提供新的措施。方法：将34名受试者随机分为沙美特罗组（n=18）和对照组（n=16）,自海拔1400m历时5天进入5200m,从进入海拔5200m当天开始,沙美特罗组每天早晚各2次吸入沙美特罗替卡松粉1个剂量（沙美特罗50μg,丙酸氟替卡松100μg）,对照组用同样的方法吸入喷完的沙美特罗替卡松粉吸入剂的空准纳器。第5天清晨空腹采肘静脉血检测一氧化氮（NO）、一氧化氮合酶（NOS）指标。结果：沙美特罗组较对照组NO增高,差异显著（P〈0.05）,NOS两组无显著性差异（P〉0.05）。结论：吸入沙美特罗替卡松粉吸入剂可提高进驻高原者的抗氧化活力,改善高原低氧环境体内氧化与抗氧化之间的平衡紊乱。

Effects of Salmeterol oR Level of NO and NOS in Young People Entering the High Altitude

Abstract Objective：To explore the effect of salmeterol on NO and NOS of transients at high altitude to prevent and treat the acute mountain sickness. Methods： 34 youth who would go to Astronomical spot （5 200m） from 1 400m altitude in 5 days, were. randomI.y divided into the salmeterol group （n=18, inhaled one dose： 50μg salmeterol and 100μg fluticasone propionate ） and the control group （n=16, inhaled empty metered--dose inhalers）. The inhalation started as soon as reaching 5 200m altitudes, twice daily in the morning and evening. On the fifth day after entering 5 200m altitudes, NO and NOS were tested. Results： As compared with control group, NO level was increased significantly （P〈0.05） and no difference between the control and salmeterol group （P〉0. 05）. Conclusions： Salmeterol can elevate content of NO and improve the balance disorder between oxidation and antioxidant because of following the high altitude.