改进甲亢围手术期服碘方法1513例临床分析

目的探讨改进甲状腺功能亢进围手术期准备的方法。方法对1996年12月～2006年12月共收治甲亢患者3015例资料进行回顾性分析,所有患者在门诊口服抗甲状腺亢进药物治疗控制症状后,随机分为改进组和常规组,其中改进组1 513例术前门诊口服碘剂,共8～11 d,术后不服碘;常规组1 502例以常规方法服碘剂。术后观察有无甲状腺危象的发生。结果2组全部病例病情稳定,甲状腺缩小、变硬,如期手术,所有患者无手术死亡,无甲状腺危象发生。结论术前门诊服碘,术后不服碘的准备方法,安全、可靠,明显缩短了甲亢围手术期外科治疗的时间,术后服碘无实际意义。

Clinical analysis of 1 513 patients with hyperthyroidism treated with modified perioperative iodine administration

Objective To investigate the modified method of perioperative preparation for hyperthyroidism.Methods We retrospectively analyzed clinical data of 3 015 patients with hyperthyroidism,from Dec.1996 to Dec.2006.In the Out-patient Department, iodine was administered orally for 8 to 11 days for predigest group(n=1 513), after taking anti-hyperthyroidism drugs to control symptoms prior to surgery, without postoperative iodine intake, compared with the control group (n=1 502)who were given iodion in common methods. Thyroid crisis of the two groups were observed after the operation.Results The two groups were stable clinically and operated on as scheduled, with diminished and hardened thyroids, but no thyroid crisis or death in the operation.Conclusion The preparation method of out-patient iodine administration before the surgery,and no postoperative iodine intake is safe and reliable.It decreases perioperative duration in surgical treatment for hyperthyroidism obviously.Postoperative iodine administration has little practical value.