| 2-(3-噻吩基)丙二酸的合成 |
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| 引用本文： | 汤文杰,胡永洲. 2-(3-噻吩基)丙二酸的合成[J]. 中国医药工业杂志, 2006, 37(8): 520-521 |
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| 作者姓名： | 汤文杰 胡永洲 |
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| 作者单位： | 浙江大学药学院药物研究所,浙江,杭州,310031 |
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| 摘 要： | 3-甲基噻吩经溴代、氰基取代制得3-噻吩乙腈，再经醇解、与碳酸二乙酯反应和碱性水解制得合成青霉素类抗生素的中间体2-（3-噻吩基）丙二酸，总收率36％。
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| 关 键 词： | 2-(3-噻吩基)丙二酸 中间体 合成 |
| 文章编号： | 1001-8255（2006）08-0520-02 |
| 收稿时间： | 2005-11-25 |
| 修稿时间： | 2005-11-25 |
Synthesis of 2-(3-Thienyl)malonic acid |
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| TANG Wen-Jie,HU Yong-Zhou. Synthesis of 2-(3-Thienyl)malonic acid[J]. , 2006, 37(8): 520-521 |
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| Authors: | TANG Wen-Jie HU Yong-Zhou |
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| Affiliation: | Dept. of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031 |
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| Abstract: | 2-(3-Thienyl)malonic acid,an intermediate for antibiotic penicillin,was synthesized from 3-methylthiophene by bromonation and cyano substitution to give 3-thienylacetonitrile,which was subjected to alcoholysis,condensation with diethyl carbonate and then hydrolysis with an overall yield of 36%. |
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| Keywords: | 2-(3-thienyl) malonic acid intermediate synthesis |
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