Stability and plasticity of wild-type and Pax5-deficient precursor B cells |
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| Authors: | Antonius G. Rolink Christoph Schaniel Fritz Melchers |
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| Affiliation: | Authors' addresses;Antonius G. Rolink1, Christoph Schaniel2, Fritz Melchers3, 1Division of Immunology, Pharmazentrum, University of Basel, Klingelbergstrasse 50, CH-4056 Basel/Switzerland.2Department of Molecular Biology, Lewis Thomas Laboratory, Room 216, Princeton University, Princeton, NJ 08544, USA.3Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel/Switzerland. |
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| Abstract: | Summary: In Pax5 -deficient mice, B cell development is blocked at the pre-BI cell stage. Like wild-type, Pax5 –/– pre-BI cells can be grown long-term in vitro in the presence of stromal cells and IL-7. However, unlike their wild-type in vitro -grown counterparts, Pax5 –/– pre-BI cells possess an extraordinary developmental plasticity showing hematopoietic stem cell features such as multipotency and self renewing capacity. Here we review and discuss this in vitro and in vivo plasticity of Pax5 –/– pre-BI cells. |
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