Oropharyngeal carriage of Candida species in HIV-infected patients in India |
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Authors: | Gugnani H C Becker K Fegeler W Basu S Chattopadhya D Baveja U Satyanarayana S Kalghatgi T Murlidhar A |
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Institution: | Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110 027, India. harishgugnani@hotmail.com |
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Abstract: | The present investigation represents the first study of oropharyngeal carriage of Candida and other yeasts in HIV-infected patients in India. One hundred and fifty HIV-positive patients were investigated by culturing their swish samples on plates of CHROMagar Candida. Ninety-eight patients (65.3%) were positive for Candida and four (2.7%) were positive for other yeasts. Among them, the first Indian C. dubliniensis isolate has been recovered. Molecular typing of selected C. albicans isolates by AP-PCR revealed two major genotypes based on the banding patterns. The susceptibilities of 30 Candida isolates to five antifungal agents including the new triazole voriconazole were determined in a micro-dilution test, according to the NCCLS protocol M 27. All the 22 C. albicans isolates were susceptible to five antimycotic agents (flucytosine, amphotericin B, fluconazole, voriconazole and itraconazole) except one isolate (VPCI-122), which was resistant to flucytosine (MIC > or = 64 mg l-1). The azole-resistant isolates reported here endorse the role of antifungal susceptibility testing whenever antifungal treatment with azoles is planned. |
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Keywords: | Candida HIV oropharyngeal carriage antifungal susceptibility India |
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