| 激素性股骨头坏死血管病理的动物实验研究 |
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| 引用本文： | 王春生,王坤正,武永刚,杨佩. 激素性股骨头坏死血管病理的动物实验研究[J]. 中华关节外科杂志(电子版), 2008, 2(1): 29-32 |
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| 作者姓名： | 王春生 王坤正 武永刚 杨佩 |
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| 作者单位： | 西安交通大学医学院第二附属医院骨科,710004 |
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| 摘 要： | 目的观察激素性股骨头坏死实验动物的血管病理改变。方法分别选用40只中国白兔随机分两组。A组：马血清＋甲基强的松龙；B组：生理盐水＋甲基强的松龙。动物分别于用药前，应用生理盐水或马血清后1d及应用用激素后第3、7、21d测定血浆内皮素（ET）、细胞间粘附分子-1（ICAM-1）和血栓调节蛋白（TM）。两组动物分别于首次注射血清或生理盐水后1周，首次应用激素后第1、3、5、7周分批处死取双侧股骨头，常规HE染色和血管内皮生长因子（VEGF）免疫组化染色。结果A组较B组有更强的血管变化；A组动物ICAM-1和TM在应用激素后3周时开始回复，而ET未见回复；两组动物的VEGF表达都表现为降低后逐渐回复的过程。结论应用激素后，实验动物的股骨头普遍存在血管病理改变，于早期这种变化具有一定的可恢复性。
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| 关 键 词： | 股骨头坏死 内皮缩血管肽类 受体 细胞粘着素 血栓调节蛋白 内皮生长因子 |
Animal experiment study on vascular pathological change of steroid-induced osteonecrosis of femoral head |
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| WANG Chun-sheng,WANG Kun-zheng,WU Yong-gang,YANG Pei. Animal experiment study on vascular pathological change of steroid-induced osteonecrosis of femoral head[J]. Chinese Journal of Joint Surgery(Electronic Version), 2008, 2(1): 29-32 |
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| Authors: | WANG Chun-sheng WANG Kun-zheng WU Yong-gang YANG Pei |
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| Affiliation: | (Department of Orthopedics, Second Affiliated Hospital of Medical College of Xian Jiaotong University, Xian 710004, China ) |
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| Abstract: | Objective Observe the vascular pathological change of animal with steroid-induced osteonecrosis of femoral head,including vessel function,vessel injury,blood viscosity and vessel regeneration.Methods 40 chinese white rabbits were randomly divided into two groups.Animal in group A were treated with horse serum and prednisone group;animal in group B were treated with prednisone.Endothelins(ET),Thrombomodulin(TM) and Intercelluar adhesion molecule-1(ICAM-1) were examined respectively before administration in t... |
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| Keywords: | Femur head necrosis Endothelins Receptors, cytoadhesin ThrombonodμLin Endothelial growth factors |
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