妊娠高血压综合征患者胎盘局部NO水平与胎盘病理改变的研究

目的 :探讨妊高征患者胎盘绒毛匀浆NO水平与胎盘绒毛病理改变的关系。方法 :用硝酸还原酶法测定40例妊高征患者和30例正常足月孕妇胎盘绒毛匀浆NO水平 ,并对受试者胎盘组织切片进行病理形态学分析。结果 :妊高征组胎盘绒毛匀浆NO水平显著低于对照组 (P<0.01) ,而胎盘绒毛病理改变发生率显著高于对照组 (P<0.01)。结论 :妊高征患者胎盘局部NO水平下降与胎盘绒毛发生病理改变两者关系密切 ,且两者可能在妊高征的发生发展中起重要作用。

Study on Nitric Oxide Level and Pathological Change of Placental Villous Tissue inPatients with Pregnancy-induced Hypertention Syndrome

Objective:To study the nitric oxide(NO)level and pathological change of placental villous tissue in patients with pregnancy-induced hypertention(PIH)syndrome.Methods:In40patients with PIH syndrome(PIH group)and30normal term pregnant women(control group),the level of NO was examined by nitrate reductase,and the placental tissue sections were analyzed by pathological morphology.Results:The level of NO of placental tissue in PIH group was significantly lower than that in control group,but the incidence rate of pathological change of placental tissue was significantly higher than that in control group(both P<0.01).Conclusion:There is the close relationship between the level of NO and the pathological change of placental tissue,both of them may play an important role in the pathogenesis of PIH.