The Mayo Clinic Biobank: A Building Block for Individualized Medicine |
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Authors: | Janet E Olson Euijung Ryu Kiley J Johnson Barbara A Koenig Karen J Maschke Jody A Morrisette Mark Liebow Paul Y Takahashi Zachary S Fredericksen Ruchi G Sharma Kari S Anderson Matthew A Hathcock Jason A Carnahan Jyotishman Pathak Noralane M Lindor Timothy J Beebe Stephen N Thibodeau James R Cerhan |
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Institution: | 1. Department of Health Sciences Research, Mayo Clinic, Rochester, MN;2. Center for Individualized Medicine, Mayo Clinic, Rochester, MN;3. Department of Medicine, Mayo Clinic, Rochester, MN;4. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN;5. Department of Social & Behavioral Sciences, Institute for Health & Aging, University of California, San Francisco;6. The Hastings Center, Garrison, NY |
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Abstract: | ObjectiveTo report the design and implementation of the first 3 years of enrollment of the Mayo Clinic Biobank.Patients and MethodsPreparations for this biobank began with a 4-day Deliberative Community Engagement with local residents to obtain community input into the design and governance of the biobank. Recruitment, which began in April 2009, is ongoing, with a target goal of 50,000. Any Mayo Clinic patient who is 18 years or older, able to consent, and a US resident is eligible to participate. Each participant completes a health history questionnaire, provides a blood sample, and allows access to existing tissue specimens and all data from their Mayo Clinic electronic medical record. A community advisory board provides ongoing advice and guidance on complex decisions.ResultsAfter 3 years of recruitment, 21,736 individuals have enrolled. Fifty-eight percent (12,498) of participants are female and 95% (20,541) of European ancestry. Median participant age is 62 years. Seventy-four percent (16,171) live in Minnesota, with 42% (9157) from Olmsted County, where the Mayo Clinic in Rochester, Minnesota, is located. The 5 most commonly self-reported conditions are hyperlipidemia (8979, 41%), hypertension (8174, 38%), osteoarthritis (6448, 30%), any cancer (6224, 29%), and gastroesophageal reflux disease (5669, 26%). Among patients with self-reported cancer, the 5 most common types are nonmelanoma skin cancer (2950, 14%), prostate cancer (1107, 12% in men), breast cancer (941, 4%), melanoma (692, 3%), and cervical cancer (240, 2% in women). Fifty-six percent (12,115) of participants have at least 15 years of electronic medical record history. To date, more than 60 projects and more than 69,000 samples have been approved for use.ConclusionThe Mayo Clinic Biobank has quickly been established as a valuable resource for researchers. |
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