早期胃癌的临床病理特征及发生淋巴结转移的危险因素研究

目的探讨早期胃癌(EGC)的临床病理特征以及发生淋巴结转移的危险因素。方法122例早期胃癌患者,根据是否发生淋巴结转移分为淋巴结未转移组(101例)和淋巴结转移组(21例)。对所有患者进行病理检查,比较两组患者的性别、年龄、镜分型、病理类型、浸润深度、分化程度、肿瘤直径、肿瘤位置,并进行Logistic回归分析,总结早期胃癌患者发生淋巴结转移的危险因素。结果两组患者的性别、年龄、病灶数、肿瘤部位、内镜分型、病理类型比较差异无统计学意义(P>0.05);淋巴结未转移组患者肿瘤直径、浸润深度、分化程度均优于淋巴结转移组,差异有统计学意义(χ2=10.499、5.333、6.228,P<0.05)。经Logistic回归分析显示,肿瘤直径≥2 cm、分化程度低以及浸润深度深是早期胃癌患者发生淋巴结转移的危险因素(P<0.05)。结论肿瘤直径≥2 cm、分化程度低以及浸润深度深是早期胃癌患者发生淋巴结转移的危险因素,通过对早期胃癌的临床病理特征进行研究,可以有效判断患者是否出现淋巴结转移的情况,对临床治疗及诊断早期胃癌有着重要意义。

Study on clinicopathological characteristics of early gastric cancer and risk factors for lymph node metastasis

Objective To discuss the clinicopathological characteristics of early gastric cancer(EGC)and risk factors for lymph node metastasis.Methods A total of 122 patients with early gastric cancer were divided into lymph node non-metastasis group(101 cases)and lymph node metastasis group(21 cases)according to whether lymph node metastasis occurred.All patients received pathological examinations.The gender,age,microscopic type,pathological type,depth of invasion,degree of differentiation,tumor diameter,tumor location of the two groups were compared,and Logistic regression analysis was performed to summarize the risk factors of lymph node metastasis in patients with early gastric cancer.Results There was no statistically significant difference in gender,age,tumor location,microscopic type and pathological type between the two groups(P>0.05).The tumor diameter,number of lesions,depth of infiltration,and degree of differentiation in patients in the nonmetastasis group was better than those of lymph node metastasis group,and the difference was statistically significant(χ2=10.499,5.333,6.228,P<0.05).Logistic regression analysis showed that tumor diameter≥2 cm,deep infiltration,low differentiation were risk factors for lymph node metastasis in patients with early gastric cancer(P<0.05).Conclusion Tumor diameter≥2 cm,deep infiltration,low differentiation are risk factors for lymph node metastasis in patients with early gastric cancer.Research on the clinicopathological characteristics of early gastric cancer can effectively determine whether patients have lymph node metastasis,which is of great significance for clinical treatment and diagnosis of early gastric cancer.