氨氯地平联合阿托伐他汀钙对老年高血压合并高脂血症患者的疗效分析

目的探讨氨氯地平联合阿托伐他汀钙在老年高血压合并高脂血症患者中的治疗效果。方法120例老年高血压合并高脂血症患者,随机分为对照组和实验组,每组60例。对照组采用氨氯地平片进行治疗,实验组采用氨氯地平联合阿托伐他汀钙片进行治疗。比较两组治疗前后血压(收缩压、舒张压)和血脂总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]水平,高脂血症治疗效果,高血压治疗效果,不良反应发生情况。结果治疗后,两组患者的收缩压、舒张压、总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平均较治疗前降低,高密度脂蛋白胆固醇水平均较治疗前升高,且实验组患者收缩压、舒张压、总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平均低于对照组,高密度脂蛋白胆固醇水平高于对照组,差异有统计学意义(P<0.05)。实验组高脂血症治疗总有效率为91.67%,高于对照组的76.78%,差异具有统计学意义(χ^2=5.065,P=0.024<0.05)。实验组高血压治疗总有效率为95.00%,高于对照组的81.67%,差异具有统计学意义(χ^2=5.175,P=0.023<0.05)。两组患者的不良反应发生率比较差异无统计学意义(χ^2=0.120,P=0.729>0.05)。结论氨氯地平联合阿托伐他汀钙治疗老年高血压合并高脂血症患者效果优于单独使用氨氯地平片,建议临床推广使用。

Effect of amlodipine combined with atorvastatin calcium on elderly patients with hypertension and hyperlipidemia

Objective To discuss the therapeutic effect of amlodipine combined with atorvastatin calcium on elderly patients with hypertension and hyperlipidemia.Methods A total of 120 patients with hypertension and hyperlipidemia were randomly divided into control group and experimental group,with 60 cases in each group.The control group was treated with amlodipine tablets,and the experimental group was treated with amlodipine combined with atorvastatin calcium tablets.The blood pressure(systolic blood pressure,diastolic blood pressure)and blood lipidstotal cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)]before and after treatment,therapeutic effect of hyperlipidemia and hypertension,and the occurrence of adverse reactions were compared between the two groups.Results After treatment,the systolic blood pressure,diastolic blood pressure,total cholesterol,triglycerides and low-density lipoprotein cholesterol of the two groups were lower than those before treatment,and high-density lipoprotein cholesterol was higher than that before treatment.The systolic blood pressure,diastolic blood pressure,total cholesterol,triglycerides and low-density lipoprotein cholesterol of the experimental group were lower than those of the control group,and high-density lipoprotein cholesterol was higher than that of the control group.The difference was statistically significant(P<0.05).The total effective rate of hyperlipidemia treatment of the experimental group was 91.67%,which was higher than 76.78%of the control group,and the difference was statistically significant(χ^2=5.065,P=0.024<0.05).The total effective rate of hypertension of the experimental group was 95.00%,which was higher than 81.67%of the control group,and the difference was statistically significant(χ^2=5.175,P=0.023<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(χ^2=0.120,P=0.729>0.05).Conclusion Amlodipine combined with atorvastatin calcium has better effect in the treatment of elderly hypertension patients with hyperlipidemia than amlodipine tablets,and it is recommended to be promoted and applied in clinic.