菌斑微生物群落构成变化与儿童龋病相关研究进展

龋病作为多因素影响的疾病,细菌是龋病发生的始动因素,生态菌斑学说的提出以及现代分子生物学手段的应用,使得学者们能够从微生物角度对菌斑生物膜中细菌的种群分布、菌群多样性、菌斑微生物群落变化与儿童龋病之间的联系进行了更深入的探讨.菌群多样性的降低与龋病发生密切相关,早于龋病发生前的6个月就可以检测到菌群多样性水平的降低,这...

Research progress on the relationship between the changes in microbial community composition of plaque and dental caries in children

Among many factors affecting dental caries,bacteria are its initiating factor.From the perspective of eco?logical plaque hypothesis,the application of modern molecular biology methods enable scholars to deeply explore the re?lationship between the microbial population distribution,biodiversity,microbial community changes of dental plaque biofilm and the occurrence of dental caries in children.The decrease in microflora diversity is closely related to the oc?currence of dental caries,which can be detected as early as 6 months before the occurrence of dental caries,providing an important basis for caries monitoring and caries risk assessment.Differential bacteria such as Lactobacillus and Veil?lonella may be used as biomarkers of caries in children to judge the risk of caries in children.However,current studies have shown that the dominant bacteria in the microbial community structure vary in different processes of caries occur?rence and development,that the interaction between different flora is still not clear,and that the specific cariogenic mechanism of the oral plaque microbial community in the process of caries occurrence and development has not been clarified.Further research is still needed to explore the changes in plaque microbial diversity and composition during the development of dental caries and to screen specific dental caries biomarkers.This paper also summarizes the related research findings.