| miR-182在三阴性乳腺癌中的表达及意义 |
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| 引用本文： | 于金玲,沈卫达,龚波,徐锦屏,高蓓敏,赵海燕.miR-182在三阴性乳腺癌中的表达及意义[J].同济大学学报(医学版),2015,36(4):29-32. |
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| 作者姓名： | 于金玲 沈卫达 龚波 徐锦屏 高蓓敏 赵海燕 |
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| 作者单位： | 上海市长宁区妇幼保健院乳腺科,上海 200051,上海市长宁区妇幼保健院乳腺科,上海 200051,上海市长宁区妇幼保健院乳腺科,上海 200051,上海市长宁区妇幼保健院乳腺科,上海 200051,上海市长宁区妇幼保健院乳腺科,上海 200051,上海市长宁区妇幼保健院乳腺科,上海 200051 |
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| 摘 要： | 目的探讨miR-182在三阴性乳腺癌中的表达及意义。方法 收集30例石蜡包埋的三阴性乳腺癌患者的癌组织和癌旁组织标本,并收集患者的基本资料。RT-PCR测定miR-182的相对表达,分析miR-182在TNBC中的表达与肿瘤的大小、分级、淋巴结转移、远处转移、TNM分期、无疾病生存率、总生存率等的相关性。结果RT-PCR结果提示,癌组织中miR-182表达为癌旁组织的8.6倍,差异有统计学意义(P＜0.001)。miR-182在淋巴结阳性及TNM分期Ⅲ期中表达高于淋巴结阴性(Z=-3.454,P=0.001)及TNM(Ⅰ+Ⅱ)期者(Z=-3.946,P=0.000),差异有统计学意义；COX回归多因素分析显示,miR-182高表达(HR=0.107,95％CI:0.018～0.643,P=0.015)、淋巴结阳性(HR=0.189,95％CI:0.020～1.757,P=0.016)、脉管瘤栓(HR=0.190,95％CI:0.020～1.826,P=0.008)、Ki67≥14％(HR=0.182,95％CI:0.041～0.801,P=0.024)、TNM分期(Ⅲ期)(HR=0.501,95％CI:0.044～5.741,P=0.001)是独立的预后因子。结论 miR-182在三阴性乳腺癌中表达上调,与淋巴结转移及临床分期相关,miR-182高表达是三阴性乳腺癌独立的预后因素之一,与预后差相关。
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| 关 键 词： | 三阴性乳腺肿瘤 miR-182 预后 侵袭 |
| 收稿时间： | 2015/2/23 0:00:00 |
Expression of microRNA-182 in triple-negative breast cancer and its clinicopathological significance |
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| YU Jin-ling,SHEN Wei-d,GONG Bo,XU Jin-ping,GAO Bei-min and ZHAO Hai-yan.Expression of microRNA-182 in triple-negative breast cancer and its clinicopathological significance[J].Journal of Tongji University(Medical Science),2015,36(4):29-32. |
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| Authors: | YU Jin-ling SHEN Wei-d GONG Bo XU Jin-ping GAO Bei-min and ZHAO Hai-yan |
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| Institution: | Dept. of Breast Surgery, Changning District Maternal and Infant Health Hospital, Shanghai 200051, China,Dept. of Breast Surgery, Changning District Maternal and Infant Health Hospital, Shanghai 200051, China,Dept. of Breast Surgery, Changning District Maternal and Infant Health Hospital, Shanghai 200051, China,Dept. of Breast Surgery, Changning District Maternal and Infant Health Hospital, Shanghai 200051, China,Dept. of Breast Surgery, Changning District Maternal and Infant Health Hospital, Shanghai 200051, China and Dept. of Breast Surgery, Changning District Maternal and Infant Health Hospital, Shanghai 200051, China |
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