| 血管位置及血管与声轴角度对HIFU表面消融效果影响的体模实验 |
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| 引用本文： | 马大钊,邹建中,杨素英,文静,曾涛,王琦.血管位置及血管与声轴角度对HIFU表面消融效果影响的体模实验[J].中国介入影像与治疗学,2017,14(7):435-438. |
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| 作者姓名： | 马大钊 邹建中 杨素英 文静 曾涛 王琦 |
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| 作者单位： | 重庆医科大学生物医学工程学院 省部共建国家重点实验室培育基地—重庆市超声医学工程重点实验室重庆市生物医学工程学重点实验室 重庆市微无创医学协同创新中心, 重庆 400016,重庆医科大学生物医学工程学院 省部共建国家重点实验室培育基地—重庆市超声医学工程重点实验室重庆市生物医学工程学重点实验室 重庆市微无创医学协同创新中心, 重庆 400016,重庆医科大学生物医学工程学院 省部共建国家重点实验室培育基地—重庆市超声医学工程重点实验室重庆市生物医学工程学重点实验室 重庆市微无创医学协同创新中心, 重庆 400016,重庆医科大学生物医学工程学院 省部共建国家重点实验室培育基地—重庆市超声医学工程重点实验室重庆市生物医学工程学重点实验室 重庆市微无创医学协同创新中心, 重庆 400016,重庆医科大学生物医学工程学院 省部共建国家重点实验室培育基地—重庆市超声医学工程重点实验室重庆市生物医学工程学重点实验室 重庆市微无创医学协同创新中心, 重庆 400016,重庆医科大学生物医学工程学院 省部共建国家重点实验室培育基地—重庆市超声医学工程重点实验室重庆市生物医学工程学重点实验室 重庆市微无创医学协同创新中心, 重庆 400016 |
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| 基金项目： | 国家重点基础研究发展计划（973计划）项目（2011CB707900）、国家重大科学仪器设备研制专项资助项目（81127901、2013YQ03062906）、国家自然科学基金面上项目（11574039、11274404）。 |
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| 摘 要： | 目的探讨靶区内血管位置及血管与声轴角度对HIFU表面消融效果的影响。方法将56块含血管的仿组织体模分为A组(血管位置)和B组(血管角度),A组按血管中心与HIFU表面消融最深层面(顶面)距离d分为A_1(d=0)、A_2(d=10mm)、A_3(d=20mm)亚组,B组按血管长轴与声轴之间夹角角度α分为B_1(0~5°)、B_2(60°~65°)、B_3(90°~95°)、B_4(115°~120°)亚组。另设A_4、B_5亚组为空白对照组。测量各组血管内径、管壁厚度,观察辐照后损伤形态,计算能效因子(EEF)。结果 A、B各亚组间血管内径、管壁厚度差异均无统计学意义(P均0.05)。损伤形态:A_1、B_1亚组靶区完全消融,无残留;余各亚组血管深侧靶区有残留。A组中A_4亚组、A_1亚组、A_2亚组(由小到大排列)EEF两两比较差异均有统计学意义(P均0.05),A_1与A_3亚组差异无统计学意义(P0.05);B组中B_5亚组、B_2亚组、B3亚组(由小到大排列)EEF两两比较差异均有统计学意义(P均0.05),B_2亚组与B_4亚组、B_5亚组与B_1亚组的EEF差异无统计学意义(P均0.05)。结论血管中心距HIFU表面消融最深层面10mm、靶区内血管与声轴角度90°~95°对靶区消融影响最大,效率最低,消融时应注意调整以提高消融效率。
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| 关 键 词： | 高强度聚焦超声消融 血管 体模 |
| 收稿时间： | 2017/3/15 0:00:00 |
| 修稿时间： | 2017/5/26 0:00:00 |
Effect of blood vessels at different locations and angle between blood vessel and sonic axis on HIFU peripheral ablation |
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| MA Dazhao,ZOU Jianzhong,YANG Suying,WEN Jing,ZENG Tao and WANG Qi.Effect of blood vessels at different locations and angle between blood vessel and sonic axis on HIFU peripheral ablation[J].Chinese Journal of Interventional Imaging and Therapy,2017,14(7):435-438. |
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| Authors: | MA Dazhao ZOU Jianzhong YANG Suying WEN Jing ZENG Tao and WANG Qi |
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| Institution: | State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medical and Biomedical Engineering, Chongqing Collaborative Innovation Center for Minimally-Invasive and Noninvasive Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China,State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medical and Biomedical Engineering, Chongqing Collaborative Innovation Center for Minimally-Invasive and Noninvasive Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China,State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medical and Biomedical Engineering, Chongqing Collaborative Innovation Center for Minimally-Invasive and Noninvasive Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China,State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medical and Biomedical Engineering, Chongqing Collaborative Innovation Center for Minimally-Invasive and Noninvasive Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China,State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medical and Biomedical Engineering, Chongqing Collaborative Innovation Center for Minimally-Invasive and Noninvasive Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China and State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medical and Biomedical Engineering, Chongqing Collaborative Innovation Center for Minimally-Invasive and Noninvasive Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China |
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| Abstract: | |
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| Keywords: | High intensity focused ultrasound ablation Blood vessels Phantom |
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