| 18F-PET/CT在肺磨玻璃结节诊断中的应用 |
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| 引用本文： | 徐丽云,褚海青,李冰,沈莉,孙秋红,赵兰.18F-PET/CT在肺磨玻璃结节诊断中的应用[J].同济大学学报(医学版),2015,36(5):61-65. |
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| 作者姓名： | 徐丽云 褚海青 李冰 沈莉 孙秋红 赵兰 |
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| 作者单位： | 同济大学附属肺科医院呼吸科,上海 200433,同济大学附属肺科医院呼吸科,上海 200433,同济大学附属肺科医院呼吸科,上海 200433,同济大学附属肺科医院呼吸科,上海 200433,同济大学附属肺科医院呼吸科,上海 200433,同济大学附属肺科医院呼吸科,上海 200433 |
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| 基金项目： | 上海市科学技术委员会医学引导项目(14411962900)；上海市科学技术委员会自然基金(12ZR1426200) |
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| 摘 要： | 目的 探讨肺恶性磨玻璃结节(ground-glass opacity, GGO)的18F-FDG PET/CT影像学特点及18F-FDG PET/CT鉴别肺GGO良恶性的诊断价值。方法 对82例行PET/CT检查的肺GGO患者的临床资料及PET/CT影像学特点行回顾分析,其中51例患者均经手术病理确诊,31例随访疗效后明确诊断。结果 82例患者中,50例为恶性病变,32例为良性病变。单因素分析显示,PET/CT下GGO的密度类型、分叶、边界、毛刺、胸膜凹陷征、充气空泡征以及标准摄取值(standardized up take value, SUV)平均值、最大值对于良恶性鉴别有意义。多因素分析显示,混合型GGO、边界不清GGO及分叶GGO是恶性GGO的预测因子。ROC曲线分析结果显示SUV最大值与平均值对于GGO的良恶性鉴别准确性较低(AUC=0.679、0.682)。结论 18F-PET/CT对恶性GGO的诊断有良好的敏感性和特异性。
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| 关 键 词： | 磨玻璃结节 肺 18F-FDG PET/CT |
| 收稿时间： | 2015/3/4 0:00:00 |
Clinical value of 18F-PET/CT for diagnosis of pulmonary ground-glass opacity nodules |
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| XU Li-yun,CHU Hai-qing,LI Bing,SHEN Li,SUN Qiu-hong and ZHAO Lan.Clinical value of 18F-PET/CT for diagnosis of pulmonary ground-glass opacity nodules[J].Journal of Tongji University(Medical Science),2015,36(5):61-65. |
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| Authors: | XU Li-yun CHU Hai-qing LI Bing SHEN Li SUN Qiu-hong and ZHAO Lan |
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| Institution: | Dept. of Respiratory Medicine, Pulmonary Hospital, Tongji University, Shanghai 200433, China,Dept. of Respiratory Medicine, Pulmonary Hospital, Tongji University, Shanghai 200433, China,Dept. of Respiratory Medicine, Pulmonary Hospital, Tongji University, Shanghai 200433, China,Dept. of Respiratory Medicine, Pulmonary Hospital, Tongji University, Shanghai 200433, China,Dept. of Respiratory Medicine, Pulmonary Hospital, Tongji University, Shanghai 200433, China and Dept. of Respiratory Medicine, Pulmonary Hospital, Tongji University, Shanghai 200433, China |
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| Abstract: | Objective To evaluate the application of 18F-FDG PET/CT imaging in diagnosis and differential diagnosis of lung ground-glass opacity(GGO) nodules. Methods The clinical data and PET/CT images of 82 patients with lung ground-glass opacity nodules were retrospectively reviewed. Among 82 cases the diagnosis was confirmed by operation and pathology in 51 cases and confirmed during follow-up in 31 cases. ResultsAmong 82 patients, 50 cases were malignant and 32 were benign. Univariate analysis showed that there were significant differences in density type, divided leaves on GGO PET/CT, boundary, burr, pleural indentation, inflatable vacuole sign, the average SUV values of SUV, SUV maximum between benign and malignant lesions. Multivariate analysis showed that mixed GGO, unclear boundary and leaf GGO was a predictor of malignancy. ROC curve showed that the accuracy of maximum SUV value and average value was low in differentiating benign and malignant GGO nodules(AUC=0.679,0.682). Conclusion 18F-PET/CT is highly sensitive and specific in diagnosis of malignant lung ground-glass nodules. |
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