A Comparison of the Effects of the Inhalation of 4% and 8% Fluroxene in the Pregnant Primate |
| |
| Authors: | Marlene Eng M.D Peter U. Berges Douglas Der Yuen J. J. Bonica Kent Ueland |
| |
| Affiliation: | Department of Anesthesiology and Anesthesia Research Center, Department of Obstetrics and Gynecology, and the Regional Primate Research Center, University of Washington, Seattle, Washington, USA. |
| |
| Abstract: | A comparison was made of the effects of inhalation of 4% fluroxene (n = 5) and 8% fluroxene (n = 5) in pregnant monkeys. Measurements of maternal arterial blood pressure, heart rate, cardiac output, total peripheral resistance, uterine blood flow, fetal heart rate and arterial blood pressure, and maternal and fetal blood gas levels were made. Inhalation of 4% fluroxene for 20 minutes produced little change in maternal hemodynamics and was well tolerated by the fetus. Fluroxene 8% inhaled for a similar 20-minute-period produced a significant decrease in maternal blood pressure (--27%), total peripheral resistance (--32%), and uterine blood flow (--27%) and lowered the level of maternal fetal exchange. |
| |
| Keywords: | |
|
|
