Central effects of sildenafil (Viagra) on auditory selective attention and verbal recognition memory in humans: a study with event-related brain potentials |
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| Authors: | D Schultheiss S V Müller W Nager C G Stief N Schlote U Jonas C Asvestis S Johannes T F Münte |
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| Institution: | (1) Department of Urology, Hannover Medical School, Germany, DE;(2) Department of Neurology, Hannover Medical School, Germany, DE;(3) Private Urologic Practice, Athens, Greece, GR;(4) Department of Clinical Neuropsychology, Otto-von-Guericke University of Magdeburg, Lennestrasse 6, 39112 Magdeburg, Germany e-mail: Thomas.muente@medizin.uni-magdeburg.de Tel.: +49-391-6714835; Fax: 49-391-6714815, DE |
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| Abstract: | The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions.
Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns
and event-related brain potentials (ERP) were recorded in a spatial auditory attention and a visual word recognition task.
While behavioral patterns did not reveal any overt effects of sildenafil, auditory ERPs were indicative of an enhanced ability
to focus attention (amplitude enhancement of Nd-effect) and to select relevant target stimuli in the sildenafil condition
(P3 component). In the memory task, CNS-effects of sildenafil were evident in a reduction of a negativity in the 150–250 ms
range. No overt effects on behavior were observed. Nevertheless, the data reveal CNS-effects of sildenafil necessitating further
studies. |
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| Keywords: | Event-related potentials Recognition memory Auditory attention Central nervous system Sildenafil |
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