| 原发性非小细胞肺癌中线粒体DNA含量变化的研究 |
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| 引用本文： | 王红梅,戴纪刚. 原发性非小细胞肺癌中线粒体DNA含量变化的研究[J]. 中国肺癌杂志, 2011, 14(2): 141-145. DOI: 10.3779/j.issn.1009-3419.2011.02.07 |
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| 作者姓名： | 王红梅 戴纪刚 |
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| 作者单位： | 第三军医大学新桥医院胸外科,重庆,400037 |
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| 摘 要： | 背景与目的已有的研究表明:线粒体DNA(mitochondrial DNA,mtDNA)突变和拷贝数的改变和肿瘤有着密切联系;大多数实体性肿瘤中mtDNA拷贝数有明显降低。本研究旨在探讨线粒体基因组含量的改变和原发性非小细胞肺癌(non-small cell lung cancer,NSCLC)的关系。方法通过实时荧光定量PCR,对肺癌及相对应的癌旁肺组织mtDNA的含量进行精确定量(拷贝数/细胞)。结果肺癌组织mtDNA的平均拷贝数/细胞为395±125,而相对应的正常肺组织为733±196,前者明显低于后者(P<0.001)。肺癌mtDNA含量的改变与患者性别、年龄、是否吸烟及肿瘤的病理类型无关(P>0.05)。结论 mtDNA含量的改变与NSCLC的发生发展密切相关,同时也可能影响其治疗和预后。
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| 关 键 词： | 线粒体DNA 肺肿瘤 突变 |
Changes on Mitochondrial DNA Content in Non-small Cell Lung Cancer |
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| Hongmei WANG,Jigang DAI. Changes on Mitochondrial DNA Content in Non-small Cell Lung Cancer[J]. Chinese journal of lung cancer, 2011, 14(2): 141-145. DOI: 10.3779/j.issn.1009-3419.2011.02.07 |
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| Authors: | Hongmei WANG Jigang DAI |
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| Affiliation: | Hongmei WANG,Jigang DAI Department of Thoracic Surgery,Xinqiao Hospital,Chongqing 400037,China |
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| Abstract: | Background and objective It has been proven that the mitochondrial DNA (mtDNA) mutations and content change were associated with increasing risk of tumorigenesis. MtDNA content is significantly reduced in most substantive tumors. The aim of this study is to demonstrate whether mtDNA content is positively associated with non-small cell lung cancer (NSCLC) risk. Methods MtDNA content in 37 matched lung carcinoma and histologically adjacent normal lung tissue samples from patients were analyzed by fluorogenic ... |
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| Keywords: | mtDNA Lung neoplasms Mutation |
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