| 非小细胞肺癌组织中ZO-1的表达及其临床意义 |
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| 引用本文： | 王晔恺,周吉航,曾芳,黄燕燕,周世权,刘晓光. 非小细胞肺癌组织中ZO-1的表达及其临床意义[J]. 中国肺癌杂志, 2011, 14(2): 146-150. DOI: 10.3779/j.issn.1009-3419.2011.02.08 |
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| 作者姓名： | 王晔恺 周吉航 曾芳 黄燕燕 周世权 刘晓光 |
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| 作者单位： | 浙江省舟山医院细胞分子生物学实验室,舟山,316004 |
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| 基金项目： | 舟山市卫生局医药科研计划项目 |
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| 摘 要： | 背景与目的 已有的研究表明紧密连接蛋白-1(zonula occluden-1,ZO-1)表达和肿瘤细胞的生长和转移存在密切联系.本研究旨在探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中ZO-1表达的临床意义.方法 应用实时荧光定量PCR、Western blot和免疫组化检...
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| 关 键 词： | ZO-1蛋白 肺肿瘤 免疫组织化学 |
Expression and Clinical Significance of ZO-1 in Patients with Non-small Cell Lung Cancer |
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| Yekai WANG,Jihang ZHOU,Fang ZENG,Yanyan HUANG,Shiquan ZHOU,Xiaoguang LIU. Expression and Clinical Significance of ZO-1 in Patients with Non-small Cell Lung Cancer[J]. Chinese journal of lung cancer, 2011, 14(2): 146-150. DOI: 10.3779/j.issn.1009-3419.2011.02.08 |
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| Authors: | Yekai WANG Jihang ZHOU Fang ZENG Yanyan HUANG Shiquan ZHOU Xiaoguang LIU |
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| Affiliation: | Yekai WANG,Jihang ZHOU,Fang ZENG,Yanyan HUANG,Shiquan ZHOU,Xiaoguang LIU Laboratory of Molecular Biology,Zhoushan Hospital,316004 Zhoushan,China |
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| Abstract: | Background and objective It has been proven that the expression of ZO-1 (zonula occluden-1) was correlated with the growth and metastasis of cancer. The aim of this study is to investigate the relationship between ZO-1 gene expression and clinicopathologic parameters and the survival rates in the patients with non-small cell lung cancer (NSCLC). Methods The expression levels of ZO-1 gene in 101 patients with NSCLC and lung tissues of 61 patients with benign lung disease were detected by real-time PCR, Weste... |
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| Keywords: | ZO-1 protein Lung neoplasms Immunohistochemistry |
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