血清胃蛋白酶原与幽门螺杆菌相关性胃炎的关系

目的]探讨血清胃蛋白酶原（serum pepsinogen,sPG）与幽门螺杆菌相关性胃炎的关系。方法]73例经胃镜及病理确诊为慢性胃炎患者,其中慢性萎缩性胃炎37例,慢性浅表性胃炎36例,对其中49例H.pylori阳性患者均给予丽珠胃三联片剂治疗,治疗前后测血清胃蛋白酶原。结果]在H.pylori感染病例中,萎缩性胃炎组与浅表性胃炎组PGⅠ值相似,而PGⅡ值萎缩性胃炎明显高于浅表性胃炎组,H.pylori阳性者高于H.pylori阴性者,PGR（PGⅠ/PGⅡ）萎缩性胃炎明显低于浅表性胃炎组,H.pylori阳性者明显低于H.pylori阴性者。经抗H.pylori治疗,87.75%的患者H.pylori被根除,H.pylori已根除的萎缩性胃炎组PGⅠ值上升,PGⅡ值下降,PGR（PGⅠ/PGⅡ）上升,H.pylori未根除的萎缩性胃炎组PGⅠ值,PGⅡ值,PGR（PGⅠ/PGⅡ）无改变,H.pylori已根除的浅表性胃炎组,PGR（PGⅠ/PGⅡ）上升。结论]H.pylori感染与sPG水平密切相关。血清PGⅠ、PGⅡ及PGR（PGⅠ/PGⅡ）对H.pylori相关萎缩性胃炎的早期诊断有一定应用价值。血清PGR（PGⅠ/PGⅡ）可作为H.pylori根除效果的评价指标。

Relativity between sPG and Gastritis of H. pylori

Objective] To explore the relativity between sPG and gastritis of H. pylori. Method] Select 73 cases of chronic gastritis correctly diagnosed by gastric microscope and pathology, among which, 36 were chronic atrophic gastritis and 36 chronic superficial gastritis. 49 cases of positive H. pylori were administered with Lizhu Weisanlian tablets, measure the sPG before and after treatment. Result] In the infected cases of H. pylori, PG Ⅰ was similar between atrophic gastritis and superficial gastritis; for PG Ⅱ value, atrophic gastritis group was more than superficial gastritis group, positive H. pylori patients higher than negative ones; PGR（PG Ⅰ/PG Ⅱ） was lower in atrophic gastritis group than superficial one, so was in positive H. pylori than negative one. After anti- H. pylori treatment, 87.75
% patients were removed H. pylori, where the PG Ⅰ rose, PG Ⅲ lowered, PGR rose in atrophic gastritis group; in the superficial one where the H. pylori was not removed, no changes happened to PG Ⅰ , PG Ⅱ and PGR. In superficial gastritis group where the H. pylori was not removed, PGR rose. Conclusion] H. pylori infection is correlated with sPG. Serum PG Ⅰ , PG Ⅱ and PGR have definite value in early diagnosing H. pylori concerned atrophic gastritis. PGR can be an index to evaluate the removal efficacy of H. pylori.