Pulmonary arterial hypertension: thin-section CT predictors of epoprostenol therapy failure |
| |
Authors: | Resten Arnaud Maître Sophie Humbert Marc Sitbon Olivier Capron Frédérique Simoneau Gérald Musset Dominique |
| |
Affiliation: | Department of Radiology, H?pital Antoine Béclère, 157 rue de la Porte de Trivaux, 92140 Clamart, France. arnaud.resten@abc.ap-hop-paris.fr |
| |
Abstract: | PURPOSE: To correlate pretherapeutic thin-section computed tomographic (CT) findings in patients with pulmonary hypertension with the risk of fatality with treatment with epoprostenol. MATERIALS AND METHODS: Seventy-three consecutive patients with severe pulmonary hypertension treated with epoprostenol were retrospectively separated into two groups. The first group included 12 patients who had a fatal outcome with epoprostenol therapy. The second group (n = 61) was a reference group of patients with epoprostenol-induced clinical improvement. Pretherapeutic thin-section CT scans of each patient were reviewed. RESULTS: Poorly defined nodular opacities (P =.003), septal lines (P =.04), pleural effusion (P =.01), and adenopathy (P =.009) strongly correlated with a risk of clinical worsening with treatment. In six patients in group 1, postmortem examination of the lung revealed either pulmonary veno-occlusive disease or pulmonary capillary hemangiomatosis. CONCLUSION: On pretherapeutic thin-section CT scans, poorly defined nodular opacities, septal lines, pleural effusion, and adenopathy should raise suspicion for pulmonary veno-occlusive disease or pulmonary capillary hemangiomatosis and provoke possible further evaluation before epoprostenol therapy. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
| 点击此处可从《Radiology》浏览原始摘要信息 |
|
点击此处可从《Radiology》下载全文 |
|