百草枯中毒致急性肺损伤的机制及其治疗进展

百草枯中毒所致急性肺损伤的机制可能与肺泡Ⅱ型细胞具有聚胺转运体而使百草枯在肺内选择性聚集,产生活性氧类物质、激活免疫系统的和释放炎性递质等有关。治疗上目前也无特效解毒剂,仍然以支持治疗为主,疗效较差。百草枯治疗的一些新方法如新型抗氧化剂、特异性百草枯抗体、肺泡表面活性物质、免疫抑制剂、血液灌流和持续静脉滤过等取得了一定进展。本文对有关百草枯所致急性损伤的机制及其治疗方面的新进展做一综述。

Research Progress in Mechanism of Acute Lung Injury Due to Paraquat Poisoning and Its Relevant Treatments

The mechanism through which Paraquat(PQ)causes Acute lung injury(ALI)has not been fully found yet.It may result from the PQ selective accumulation in lungs due to participation of the polyamine transportor system abundantly expressed in the membrane of alveolar type II cells,which generates active oxygen substances,activates immune system and releases inflammation mediators.Now managements of PQ poisoning rely mainly on supporting therapy,but the efficacies are poor.So far,there are no true pharmacological antagonists or chelating agents found,which are capable of binding the PQ poison in the lung tissues.Some progress has been achieved in the treatment of PQ poisoning such as use of new antioxidants,PQ-specific antibodies,alveolar surfactant,immunosuppressive agents,hemoperfusion and continuous veno-venous hemofiltration(CVVH)etc,but these methods have failed to alter the final outcomes in poisoned patients.This paper reviews the new progress in research of the mechanisms of PQ-poisoning-caused ALI and its treatments.