糖肾通宝饮联合贝那普利治疗临床期糖尿病肾病31例疗效观察

目的 观察中药糖肾通宝饮联合贝那普利治疗临床期糖尿病肾病(diabetic nephropathy,DN)患者肾功能的临床疗效.方法 采用随机、对照方法,将62例临床期DN患者分为两组各31例.两组均给了相同饮食、降糖和对症处理,治疗组应用中药糖肾通宝饮联合贝那普利治疗,对照组应用胰激肽原酶肠溶片合贝那普利治疗,疗程均为8周,观察2组患者治疗前后症状体征变化,测定24h尿蛋白总量(24-hour urinay protein,24h Upro)、血肌酐(serumcreatimine,SCr),肌酐清除率(serum creatinine clearance erate,CCr)尿素氮(blood urea nitrogen,BUN)、三酰甘油(triglyceride,TG)、总胆崮醇(cholesterd,CHO)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)的变化.结果 治疗组治疗后24hUpro、SCr、TG、CHO、LDL-C均降低(P<0.01或P<0.05),优于对照组.结论 中药糖肾通宝饮联合贝那普利方案治疗临床期DN可明显降低24hUpro,SCr,降脂作用优于单纯西药.

Observation On the Curative Effect of Tangshentongbao Decoction Combined Benazepril on 31Cases of Diabetic Nephropathy in Clinical Stage

Objective To assess the protective effect of Tangshentongbao decoction combined benazepril on renal function of the patients with diabetic nephropathy(DN) in clinical stage and to make a effective contrast to the therapy with western medicine. Methods 62 patients with DN in clinical stage were randomly divided into a control group and a treatment group, with 31 patients in each group. Both groups were supplied with the same food, adopted glucose control therapy and symptoms orientated treatment. On these basis, the treatment group was administered with Tangshentongbao decoction combined benazepril, and the control group was taken kallikrein enteric tablet combined benazepril. The therapeutic courses for both groups were 8 months. The changes of symptoms and physical signs, 24-hour urinay protein (24hUpro), serum cteatimine (SCr), serum creatinine clearance erate (CCr) , blood urea nitrogen (BUN), triglyceride (TG), cholesterd (CHO) and low density lipoprotein-cholesterol (LDL-C)of the two groups were separately assessed. Results 24hUpro, SCr, TG, CHO and LDL-C of treated group were all reduced after the treatment (P<0.01 or P <0.05), showing significant difference compared with the control group. Conclusion 24hUpro and SCr of patients with DN in clinical stage can be evidently reduced by Tangshentongbao decoction, and the effect of reducing blood lipid is remarkable better than western medicine alone.