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| 去氢表雄酮硫酸酯钠盐对妊娠大鼠子宫颈张力的影响及作用机理 | |
| 引用本文： | 左晓春,乔凤霞,王乃功,周兰芳,关慕贞. 去氢表雄酮硫酸酯钠盐对妊娠大鼠子宫颈张力的影响及作用机理[J]. 药学学报, 1993, 0(6) |
| 作者姓名： | 左晓春 乔凤霞 王乃功 周兰芳 关慕贞 |
| 作者单位： | 中国医学科学院药物研究所，中国医学科学院药物研究所，中国医学科学院药物研究所，中国医学科学院药物研究所，中国医学科学院药物研究所 北京 100050，北京 100050，北京 100050，北京 100050，北京 100050 |
| 摘 要： | 去氢表雄酮硫酸酯为正常人体肾上腺所分泌,是合成雄激素和雌激素的前体。1970年日本钟仿制药厂正式生产该产品作为宫颈成熟剂,用于治疗宫颈成熟不全和产程延长等。Mochizuki给妊娠末期的妇女ⅳ去氢表雄酮硫酸酯钠盐(OHA-S)100 mg,共2次,发现DHA-S能促进子 |
EFFECT OF DIHYDROEPIANDROSTERONE SULFATE ON THE TENSION OF UTERINE CERVIX AND ITS MECHANISMS |
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| XC Zuo,FX Qiao,NG Wang,LF Zhou and MZ Guan. EFFECT OF DIHYDROEPIANDROSTERONE SULFATE ON THE TENSION OF UTERINE CERVIX AND ITS MECHANISMS[J]. Acta pharmaceutica Sinica, 1993, 0(6) | |
| Authors: | XC Zuo FX Qiao NG Wang LF Zhou MZ Guan |
| Abstract: | After iv injection of dihydroepiandrosterone sulfate (DHA-S) at 20 or 40 mg/kg to female rats on day 19 of gestation, the tension and hydroxyproline level of uterine cervix were decreased obviously. However, DHA-S at 10 mg/kg showed no effect on the tension of uterine cervix. DHA-S in vitro, at 0.1 mg/kg significantly increased estradiol secretion in the ovaries and placenta of late pregnant rats. |
| Keywords: | Dihydroepiandrosterone sulfate Uterine cervix Hydroxyproline Estradiol |
| 本文献已被 CNKI 等数据库收录！ | |