严重急性呼吸综合征患者血清超氧化物歧化酶含量的动态观察

目的观察SAPS患者血清超氧化物歧化酶(SOD)含量变化。方法用放射免疫法检测29例SAILS患者血清SOD含量，与正常对照组作了比较。结果患者SOD含量明显低于对照组，重型SARS患者SOD含量明显低于普通型。恢复期不同阶段患者血清SOD含量回升但仍低于对照组。结论SAILS患者体内产生过量的自由基分子，使SOD过度消耗。SOD含量变化可以反映病情程度，检测血清SOD水平有助于病情的观察。加强机体清除自由基的能力可能是重要的治疗措施之一。

The Level Change of Serum Superoxide Dismutase in Patients with Severe Acute Respiratory Syndrome

Objective To observe the level change of serum SOD in patients with severe acute respiratory syndrome (SARS). Methods The levels of serum SOD in 66 patients with SARS were measured by RIA, and compared with controls. Results The levels of serum SOD in patients with SARS were significantly lower than those in controls, and in severe type of SARS patients were lower than those in the other types. The levels of serum SOD in the recovery stage of SARS patients increased, but still was lower than those in controls. Conclusion Excessive free radicals were produced in patients with SARS, and SOD was depleted. The level change of SOD in patients with SARS may reflect state of disease. Dynamic detection of serum SOD level is helpful for monitoring state of SARS. It may be an important therapeutic measure that excessive free radicals were eliminated from SARS patient body.