珊瑚人工骨修复兔颅骨缺损的骨组织形态测量学研究

为对国产滨珊瑚的骨修复的作用作初步评估，将２０～４０目颗粒滨珊瑚植入兔颅骨直径１．５ｃｍ的缺损区，以羟基磷灰石，空白为对照，分别于术后第２，４，８及１２周取材，作组织学和组织形态测量学观察，结果发现，植入缺损区的珊瑚随时间推移逐渐降解，同时新骨不断长入，至术后第１２周珊瑚完全降解，新骨修复缺损中心区，新骨所占百分比为３６．９％，与对照组比较有显著差异（Ｐ〈０．０１）。认为珊瑚人工骨具有良好的内传导

EXPERIMENTAL STUDY OF CORAL IMPLANTATION IN REPAIR OF SKULL BONE DEFECT IN RABBIT: HISTOMORPHOMETRY OF BONE/

In order to evaluate coral as a bone graft substitute in repair of bone defect, particulates of coral were implanted into skull bone defect of rabbit, 1.5 cm in diameter. Hydroxyapatite and blank were taken as controls. The rabbits were sacrificed at the second, fourth, eighth and twelveth weeks after the operation. The specimens were taken and performed histological examination and histomorphometry observation. Results were as follows: at the second week many multinucleus giant cells infiltrated. As time elapsed, the coral were progressively degenerated and new bone was formed to fill the defect. Up to the twelveth week, the coral degenerated completely and new bone formed in the center of the defect. Percentage of new bone was in defect was 36.9%. Compared with the controls, there were significant differences (P< 0.01 ). It was suggested that coral had good osteoconductility. Howevel, coral underwent rapid degeneration, it might result in inconplete repair of bone defect.