Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy

Abstract

Objectives:

Present study aims to investigate the ameliorative effects of naringenin (NG) on experimentally induced diabetic neuropathy (DN) in rats.

Methods:

Diabetes was induced by single intraperitoneal injection of streptozotocin (STZ, 60?mg/kg). Naringenin (25 and 50?mg/kg/day) treatment was started 2?weeks after the diabetes induction and continued for five consecutive weeks. Pain threshold behaviour tests were performed at the end of the treatment. Serum levels of glucose, insulin and pro-inflammatory cytokines were assessed. In sciatic tissues, markers oxidative stress, cytokines and neurotrophic factors were measured.

Results:

NG treatments showed significant decrease in paw-withdrawal (P?P?Discussion:

We suggest that neuro-protective effect of NG molecules in sciatic nerve of diabetic rats, through its anti-diabetic as well as antioxidant and anti-inflammatory properties.