Estrogenic activities of chemicals in diesel exhaust particles |
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| Authors: | Mori Yoki Taneda Shinji Hayashi Hideyuki Sakushima Akiyo Kamata Kazuyuki Suzuki Akira K Yoshino Shin Sakata Masakatsu Sagai Masaru Seki Koh-ichi |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan. mori@hoku-iryo-u.ac.jp |
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| Abstract: | In a previous study, we focused on estrogenic activity of the hexane extract of diesel exhaust particles (DEP). The extract of hexane was first fractionated to acidic, phenolic and neutral portions according to their chemical properties, of which the neutral fraction was fractionated by column chromatography on silica gel. The chemical structures of compounds in these fractions were then analyzed. It was found that the neutral fraction of the hexane extract of DEP contains dibenzothiophene derivatives, one of which, 4,6-dimethyldibenzothiophene, possesses estrogenic activity. |
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