| 玉竹水提物对大鼠血栓形成的影响 |
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| 引用本文： | 邓藻镛,程全芬.玉竹水提物对大鼠血栓形成的影响[J].实用心脑肺血管病杂志,2012,20(7):1131-1132. |
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| 作者姓名： | 邓藻镛 程全芬 |
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| 作者单位： | 1. 四川省革命伤残军人医院药剂科,四川省成都市,610500
2. 成都市新都区第二人民医院药剂科 |
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| 摘 要： | 目的探讨玉竹水提物抗血栓形成的作用及机制。方法利用大鼠动-静脉旁路血栓形成模型测定给予玉竹水提物后血栓湿重和干重,同时测定大鼠血浆血栓烷B2(TXB2)和6-酮-前列腺素F1α(6-keto-PGF1α)的含量。结果玉竹水提物可明显抑制大鼠动-静脉旁路血栓形成,减轻血栓湿重和干重,同时降低血浆中TXB2的含量,增加血浆中6-keto-PGF1α的含量。结论玉竹水提物可明显抑制大鼠血栓形成,其机制可能与降低血浆中TXB2的含量和增加血浆中6-keto-PGF1α的含量有关。
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| 关 键 词： | 玉竹 血栓形成 血栓烷B2 6-酮-前列腺素F1α |
Effects of E-PAOA on Experimental Thrombosis in Rats |
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| DENG Zao-yong
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CHENG Quan-fen.Effects of E-PAOA on Experimental Thrombosis in Rats[J].Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease,2012,20(7):1131-1132. |
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| Authors: | DENG Zao-yong CHENG Quan-fen |
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| Institution: | .Department of Pharmacy,the Revolution Disability Soldiers′s Hospital of Sichuan,Chengdu 610500,China |
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| Abstract: | Objective To study the effect of the extract of Polygonatum odoratum(E-PAOA) on thrombus formation and its mechanisms.Methods The rat models of artery-vein bypass thrombosis were used to measure the thrombus weight and the levels of TXB2 and 6-keto-PGF1α in plasma.Results After treated with E-PAOA,thrombus weight and the levels of TXB2 were reduced,while levels of 6-keto-PGF1α were increased.Conclusion E-PAOA exerted remarkable effects against the thrombosis,and its mechanisms might be associated with reduction of TXB2 level and increase of 6-keto-PGF1α level. |
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| Keywords: | POLYGONATUM ODORATUM Thrombosis TXB2 6-keto-PGF1α |
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