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Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene.
Authors:J A Menendez  L Vellon  R Lupu
Affiliation:Department of Medicine, Breast Cancer Translational Research Program, Evanston Northwestern Healthcare Research Institute, Evanston, IL, USA. jmenendez@enh.org
Abstract:
Keywords:orlistat   fatty acid synthase   Her2/neu   PEA3   trastuzumab   breast cancer
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