|
|||||
|
|
Neutralization of kinin-releasing enzymes from viperid venoms by antivenom IgG fragments |
|
| Authors: | Abdusalam Al-Joufi Graham S Bailey Krisana Reddi and Damon C Smith |
| Institution: | 1 Department of Chemistry and Biological Chemistry, University of Essex, Colchester, CO4 3SQ, U.K. 2 Therapeutic Antibodies Inc., The Medical College of St Barts Hospital, London, EC1M 7BG, U.K. |
| Abstract: | The activities of kinin-releasing enzymes in the venoms of Vipera xanthina xanthina, V. lebetina obtusa, V. aspis aspis, V. lebetina schweizeri, V. ammodytes ammodytes and V. berus berus were determined using a specific radioimmunoassay for kinin. The kinin-releasing activities of all the viperid venoms measured in vitro were neutralized, to varying extents, by two commercially available monospecific antivenoms in the form of F(ab′)2 (Zagreb) and Fab (TAb) immunoglobin fragments, indicating a high degree of cross-neutralization of those enzymes. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |