Recreational physical activity and survival in African-American women with ovarian cancer |
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| Authors: | Sarah E. Abbott Fabian Camacho Lauren C. Peres Anthony J. Alberg Elisa V. Bandera Melissa Bondy Michele L. Cote Ellen Funkhouser Patricia G. Moorman Edward S. Peters Bo Qin Ann G. Schwartz Jill Barnholtz-Sloan Paul Terry Joellen M. Schildkraut |
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| Affiliation: | 1.Department of Public Health Sciences,University of Virginia,Charlottesville,USA;2.Department of Epidemiology and Biostatistics, Arnold School of Public Health,University of South Carolina,Columbia,USA;3.Department of Population Science,Rutgers Cancer Institute of New Jersey,New Brunswick,USA;4.Department of Medicine, Section of Epidemiology and Population Sciences,Baylor College of Medicine,Houston,USA;5.Department of Oncology and the Karmanos Cancer Institute Population Studies and Disparities Research Program,Wayne State University,Detroit,USA;6.Division of Preventive Medicine,University of Alabama at Birmingham,Birmingham,USA;7.Department of Community and Family Medicine,Duke University Medical Center,Durham,USA;8.Epidemiology Program,Louisiana State University Health Sciences Center School of Public Health,New Orleans,USA;9.Case Comprehensive Cancer Center,Case Western Reserve University School of Medicine,Cleveland,USA;10.Department of Medicine,University of Tennessee Medical Center-Knoxville,Knoxville,USA |
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| Abstract: | PurposeWhile recreational physical activity (RPA) has been associated with reduced mortality in breast, colorectal, and prostate cancers, evidence for epithelial ovarian cancer (EOC) is limited. Most EOC studies have been in predominantly white populations, although inactivity is more prevalent and survival is poorer among African-American (AA) women. We examined RPA before and after EOC diagnosis and associations with survival among AA women.MethodsWe analyzed data from 264 EOC survivors enrolled in a population-based, case–control study who completed surveys that included questions about pre- and post-diagnosis RPA. Data were collected on RPA frequency, intensity, and duration before diagnosis and approximately 1 year after the baseline interview. We calculated metabolic equivalent of task (MET)-hours/week for pre- and post-diagnosis RPA, and evaluated associations with risk of mortality using Cox proportional hazards models.ResultsRPA before diagnosis was not associated with mortality. Hazard ratios (HRs) for post-diagnosis RPA were ?0–9 MET-hours/week and 0.53 (95% CI 0.21, 1.35) for >?9 MET-hours/week.ConclusionsOur results suggest that RPA may be inversely associated with mortality among AA women with ovarian cancer, although it is possible that the present study was underpowered to detect an association. There is a clear need for more studies of RPA after diagnosis in EOC survivors with attention to potential differences by race. |
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