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Comparison of radiographic and magnetic resonance imaging findings of early osteoarthritis of the rabbit knees: an experimental study
Authors:Behrooz Nikahval  Seifollah Dehghani Nazhvani  Mohammad Hadi Bagheri  Nader Tanideh  Mehrangiz Keramati  Hamid Reza Gheisari
Affiliation:1. Department of Surgery and Radiology, School of Veterinary Medicine, Shiraz University, PO Box 1731-71345, Shiraz, Iran
2. Department of Radiology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
3. Stem Cell and Transgenic Technology Research Center, Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran
4. Department of Food Hygiene and Public Health, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Abstract:The objectives of the present study were to describe radiographic and magnetic resonance imaging (MRI) findings of early osteoarthritis and their relationships at the same time. A total number of ten rabbits were used and randomly divided into two equal groups. In one group, cranial cruciate ligament (CCL) of the left knee was transected to produce experimental osteoarthritis and in the other group, only the articular capsule was entered as sham operation (arthrotomy group). All of the left knees were examined by MRI and radiography before operation to exclude preexisting abnormalities and serve as control. One month postoperation, two conventional radiographic views and MR imaging were performed under general anesthesia. Statistical analysis of the MRI results revealed that there was a significant difference between the CCL-transected group with arthrotomy and control groups. There was no significant difference in the radiographic findings between the operated, arthrotomy and control groups. It was concluded that osteoarthritic changes of the joints can be detectable 1?month postinjury by MRI. Meniscal degeneration and subchondral bone irregularity are detectable diagnostic signs.
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