The presence of immunosuppressive ''p15E-like'' factors in the serum and urine of patients suffering from malign and benign breast tumours. |
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Authors: | H St ger, M Wilders-Truschnig, H Samonigg, M Schmid, T Bauernhofer, A Tiran, M Tas, H A Drexhage |
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Affiliation: | H Stöger, M Wilders-Truschnig, H Samonigg, M Schmid, T Bauernhofer, A Tiran, M Tas, and H A Drexhage |
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Abstract: | Autoantibodies in sera from patients with systemic lupus erythematosus (SLE) and onchocerciasis recognize calreticulin (CaR), a calcium-binding protein, as antigen. In this study we present the immunological properties of two synthetic peptides prepared to correspond to the 1-24 and 7-24 amino acid sequence of CaR. In contrast to information previously reported for the recombinant protein, the CaR-peptide analogues appeared immunoreactive to anti-Ro/SSA autoimmune sera. Human sera from patients with SLE, Sjögren's syndrome (SS), rheumatoid arthritis (RA), as well as mixed connective tissue disease (MCTD), demonstrated a positive autoimmune response (binding of antibodies), to the CaR-peptide analogues. These findings suggest that anti-calreticulin autoantibodies are not restricted to any disease specificity. |
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Keywords: | Vβ repertoire superantigen HIV low CD4+ T cell counts |
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